公开(公告)号：EP4313135A1

公开(公告)日：2024-02-07

申请号：EP22714610.7

申请日：2022-03-31

申请人： Janssen Pharmaceuticals, Inc.

发明人： WEERDENBURG, Eveline, Marleen ,  GEURTSEN, Jeroen ,  BURGHOUT, Pieter Jan

IPC分类号： A61K39/108 ,  A61P13/02

公开(公告)号：EP4277921A1

公开(公告)日：2023-11-22

申请号：EP22700099.9

申请日：2022-01-11

申请人： Janssen Pharmaceuticals, Inc.

发明人： GRIJPSTRA, Jan ,  WEERDENBURG, Eveline, Marleen ,  GEURTSEN, Jeroen ,  FAE, Kellen, Cristhina ,  FEITSMA, Louris, Jakob

IPC分类号： C07K14/245 ,  A61P13/00

公开(公告)号：EP3942028A1

公开(公告)日：2022-01-26

申请号：EP20718990.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA, FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12N9/10 ,  C12P21/00

公开(公告)号：EP4461744A2

公开(公告)日：2024-11-13

申请号：EP24189800.6

申请日：2021-01-14

申请人： Janssen Pharmaceuticals, Inc.

发明人： GRIJPSTRA, Jan ,  WEERDENBURG, Eveline, Marleen ,  GEURTSEN, Jeroen ,  FAE, Kellen, Cristhina ,  FEITSMA, Louris, Jakob

IPC分类号： C07K16/12

摘要： Polypeptides comprising FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：EP4253554A3

公开(公告)日：2024-01-17

申请号：EP23177116.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12N9/10 ,  C12P21/00

摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E . coli. (ExPEC).

公开(公告)号：EP4253554A2

公开(公告)日：2023-10-04

申请号：EP23177116.3

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： C12P21/00

摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E . coli. (ExPEC).

公开(公告)号：EP4090363A1

公开(公告)日：2022-11-23

申请号：EP21700027.2

申请日：2021-01-14

申请人： Janssen Pharmaceuticals, Inc.

发明人： GRIJPSTRA, Jan ,  WEERDENBURG, Eveline, Marleen ,  GEURTSEN, Jeroen ,  FAE, Kellen, Cristhina ,  FEITSMA, Louris, Jakob

IPC分类号： A61K39/108 ,  C07K14/245 ,  A61K39/00 ,  C07K16/12

公开(公告)号：EP3941516A1

公开(公告)日：2022-01-26

申请号：EP20718989.5

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： GEURTSEN, Jeroen ,  POOLMAN, Jan, Theunis ,  FAE, Kellen, Cristhina ,  BURGHOUT, Pieter, Jan ,  WEERDENBURG, Eveline, Marleen ,  IBARRA YON, Patricia ,  ABBANAT, Darren, Robert ,  KEMMLER, Stefan, Jochen ,  KOWARIK, Michael, Thomas ,  MALLY, Manuela ,  GAMBILLARA FONCK, Veronica ,  BRAUN, Martin, Edward ,  CARRANZA SANDMEIER, Maria, Paula

IPC分类号： A61K39/108 ,  A61P13/02