公开(公告)号：EP2097402B1

公开(公告)日：2014-04-09

申请号：EP07822656.0

申请日：2007-11-16

申请人： Janssen R&D Ireland

发明人： RABOISSON, Pierre Jean-Marie Bernard ,  DE KOCK, Herman Augustinus ,  MC GOWAN, David Craig ,  VAN DE VREKEN, Wim ,  HU, Lili ,  TAHRI, Abdellah ,  VENDEVILLE, Sandrine Marie Helene

IPC分类号： C07D401/12 ,  C07D491/04 ,  A61K31/4709 ,  A61K31/4741 ,  A61P31/14

CPC分类号： C07D491/056 ,  A61K31/427 ,  A61K31/4741 ,  C07D401/12 ,  C07D491/04 ,  C07D491/048 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393 ,  A61K2300/00

摘要： Inhibitors of HCV replication of formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 is C1-6alkyl or C3-7cycloalkyl; R5 is hydrogen, halo, C1-6alkyl, hydroxy, C1-6alkoxy, polyhaloC1-6alkyl; R6 is hydrogen, C1-6alkoxy, mono- or diC1-6alkylamino; or R5 and R6 may form a 5- or 6-membered unsaturated or partially unsaturated ring, optionally comprising one or two selected from O, N and S; R7 is hydrogen; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl; R8 is C3-7cycloalkyl optionally substituted with C1-6alkyl; C1-6alkyl optionally substituted with C3-7cycloalkyl; or -NR8aR8b; R8a and R8b are C1-6alkyl, or both may form a 5- or 6-membered saturated heterocyclic ring; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).

公开(公告)号：EP2812331A1

公开(公告)日：2014-12-17

申请号：EP13703055.7

申请日：2013-02-07

申请人： Janssen R&D Ireland

发明人： MC GOWAN, David Craig ,  RABOISSON, Pierre Jean-Marie Bernard ,  JONCKERS, Tim Hugo Maria ,  DAOUBI KHAMLICHI, Mourad

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P31/00

CPC分类号： C07D471/04 ,  A61K31/519

摘要： This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

公开(公告)号：EP2776439A1

公开(公告)日：2014-09-17

申请号：EP12784574.1

申请日：2012-11-08

申请人： Janssen R&D Ireland

发明人： BONFANTI, Jean-François ,  DOUBLET, Frédéric Marc Maurice ,  EMBRECHTS, Werner ,  FORTIN, Jérôme Michel Claude ,  MC GOWAN, David Craig ,  MULLER, Philippe ,  RABOISSON, Pierre Jean-Marie Bernard

IPC分类号： C07D473/34 ,  A61K31/522 ,  A61P31/12 ,  C07D519/00

CPC分类号： C07D473/34 ,  C07D473/16 ,  C07D519/00 ,  C07F9/65616

摘要： The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.