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公开(公告)号：EP3836961A1
公开(公告)日：2021-06-23
申请号：EP19749566.6
申请日：2019-08-13
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公开(公告)号：EP4297778A1
公开(公告)日：2024-01-03
申请号：EP22707124.8
申请日：2022-02-22
IPC分类号： A61K39/12 , A61K39/21 , A61P31/18 , C07K14/005 , C07K14/16
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公开(公告)号：EP4126023A1
公开(公告)日：2023-02-08
申请号：EP21714920.2
申请日：2021-04-01
发明人： RITSCHEL, Tina , VOORZAAT, Richard , RUTTEN, Lucy , JONGENEELEN, Mandy, Antonia, Catharina , JONCKERS, Tim, Hugo, Maria , ROYMANS, Dirk, André, Emmy , LANGEDIJK, Johannes, Petrus, Maria
IPC分类号： A61K39/12 , A61K31/00 , A61K39/145 , A61K39/155 , A61K39/21 , A61P31/14 , A61P31/16 , A61P31/18
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公开(公告)号：EP3512543B1
公开(公告)日：2020-07-22
申请号：EP17769027.8
申请日：2017-09-14
IPC分类号： A61K39/12 , C07K14/005
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公开(公告)号：EP3655032A1
公开(公告)日：2020-05-27
申请号：EP18737921.9
申请日：2018-07-12
IPC分类号： A61K39/12 , C07K14/005
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公开(公告)号：EP3512543A1
公开(公告)日：2019-07-24
申请号：EP17769027.8
申请日：2017-09-14
IPC分类号： A61K39/12 , C07K14/005
摘要： Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins have certain amino acid substitutions at specified positions in the envelope protein sequence. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to an HIV envelope protein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, nucleic acid, and vectors.
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