公开(公告)号：EP3594213A1

公开(公告)日：2020-01-15

申请号：EP19188636.5

申请日：2010-07-16

申请人： Japan Tobacco Inc.

发明人： Mitani, Ikuo ,  Ogoshi, Yosuke ,  Matsui, Takuya ,  Yokota, Masahiro ,  Terashita, Masakazu ,  Motoda, Dai ,  Ueyama, Kazuhito ,  Abe, Hiroyuki ,  Hotta, Takahiro ,  Ito, Takashi

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P7/06 ,  A61P43/00

摘要： The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The present invention relates to a compound represented by the following

wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as a prolyl hydroxylase inhibitor or erythropoietin production-inducing agent containing the compound. The compound of the present invention shows a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability and is useful as a prophylactic or therapeutic agent for various diseases and pathologies (disorders) caused by decreased production of erythropoietin.

公开(公告)号：EP3456713A1

公开(公告)日：2019-03-20

申请号：EP18201469.6

申请日：2015-02-19

申请人： Japan Tobacco Inc.

发明人： Nagamori, Hironobu ,  Mitani, Ikuo ,  Yamashita, Masaki ,  Hotta, Takahiro ,  Nakagawa, Yuichi ,  Ueda, Masatoshi

IPC分类号： C07D251/22 ,  A61K31/53 ,  A61P9/10 ,  A61P17/00 ,  A61P19/02 ,  A61P25/00 ,  A61P25/28 ,  A61P27/06 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D405/12 ,  C07D471/10

摘要： Provided is a process for the production of a compound represented by the formula [I] or a pharmaceutically acceptable salt thereof:

wherein each symbol is as defined in the specification. Said compound has an mPGES-1 inhibitory activity and is useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.