公开(公告)号：EP2841111B1

公开(公告)日：2016-06-01

申请号：EP13731163.5

申请日：2013-04-27

申请人： Jawaharlal Nehru Centre For Advanced Scientific Research ,  Université de Strasbourg

发明人： KUNDU, Tapas Kumar ,  BOUTILLIER, Anne-Laurence ,  CHATTERJEE, Snehajyoti ,  ESWARAMOORTHY, Muthusamy ,  MIZAR, Pushpak ,  MATHIS, Chantal ,  CASSEL, Jean-Christophe ,  NEIDL, Romain ,  VASUDEVARAO, Mohankrishna Dalvoy, ,  MAHESHWARAPPA, Vedamurthy Bhusainahalli,

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K31/167 ,  A61P25/28

CPC分类号： A61K47/48861 ,  A61K31/167 ,  A61K47/48869 ,  A61K47/6923 ,  A61K47/6925 ,  A61K49/0093 ,  C07K14/47

公开(公告)号：EP2841111A1

公开(公告)日：2015-03-04

申请号：EP13731163.5

申请日：2013-04-27

申请人： Jawaharlal Nehru Centre For Advanced Scientific Research ,  Université de Strasbourg

发明人： KUNDU, Tapas Kumar ,  BOUTILLIER, Anne-Laurence ,  CHATTERJEE, Snehajyoti ,  ESWARAMOORTHY, Muthusamy ,  MIZAR, Pushpak ,  MATHIS, Chantal ,  CASSEL, Jean-Christophe ,  NEIDL, Romain ,  VASUDEVARAO, Mohankrishna Dalvoy, ,  MAHESHWARAPPA, Vedamurthy Bhusainahalli,

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61P25/28

CPC分类号： A61K47/48861 ,  A61K31/167 ,  A61K47/48869 ,  A61K47/6923 ,  A61K47/6925 ,  A61K49/0093 ,  C07K14/47

摘要： The present disclosure is in relation to a composition comprising nanosphere and histone acetyltransferase (HAT) activator. The disclosed nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide [COMPOUND 1]. The said N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present disclosure further relates to a process for obtaining a composition comprising carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl- phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The said composition thus provides for managing pathological conditions to a subject in need thereof, such as aging- related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit.

公开(公告)号：EP4240874A1

公开(公告)日：2023-09-13

申请号：EP21801567.5

申请日：2021-11-05

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Centre Hospitalier Universitaire de Lille ,  université de Lille ,  Université de Strasbourg

发明人： GIACOBINI, Paolo ,  PREVOT, Vincent ,  BOUTILLIER, Anne-Laurence ,  MIMOUNI, Nour El Houda ,  PAIVA DE CASTRO, Isabel

IPC分类号： C12Q1/6883 ,  A61K31/00