公开(公告)号：EP4269447A1

公开(公告)日：2023-11-01

申请号：EP21909437.2

申请日：2021-12-22

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd

发明人： WANG, Huan ,  LIN, Yuan ,  TANG, Yucheng ,  KE, Ke ,  LIN, Kan ,  LIAO, Cheng

IPC分类号： C07K19/00 ,  C07K16/30 ,  C12N15/62 ,  A61P35/00

摘要： Provided are a complex of an anti-IL-4R antibody or an antigen-binding fragment thereof, and a medical use thereof. Specifically, provided are a complex of an antibody that specifically binds to IL-4R or an antigen-binding fragment thereof covalently linked to a toxin, a pharmaceutical composition comprising the complex, and a use thereof in the preparation of a drug for treating IL-4R-mediated diseases or disorders, especially a use in the preparation of an anti-cancer drug.