公开(公告)号：EP4011375A1

公开(公告)日：2022-06-15

申请号：EP20850324.3

申请日：2020-08-05

申请人： Jiangsu Yahong Meditech Co., Ltd. ,  Shanghai Yahong Meditech Co., Ltd.

发明人： LIU, Jianghua ,  GUO, Yushen ,  SHEN, Shuai ,  ZHU, Wei

IPC分类号： A61K31/47 ,  A61K47/20 ,  A61K47/12 ,  A61K9/20 ,  A61K9/36 ,  A61P35/00

摘要： A pharmaceutical composition containing nitroxoline for the treatment of bladder cancer, a nitroxoline oral solid tablet, a preparation method therefor and use thereof. The pharmaceutical composition comprises nitroxoline, a filler, a disintegrating agent, a binder, and a lubricant. The lubricant is selected from one or two of sodium dodecyl sulfate and sodium stearyl fumarate. The pharmaceutical composition has a moderate dissolution rate, can avoid the burst release phenomenon, is moisture-proof and impermeable, has good stability, is secure and effective, is convenient to take, has strong patient compliance, and meets the requirements of being an oral solid tablet. The preparation method has stable production process, good reproducibility, easy mass production, and good clinical use value and social benefits.

公开(公告)号：EP4085902A1

公开(公告)日：2022-11-09

申请号：EP20908545.5

申请日：2020-12-30

申请人： Jiangsu Yahong Meditech Co., Ltd. ,  Asieris Pharmaceuticals (Shanghai) Co., Ltd.

发明人： CHEN, Jie ,  SHEN, Shuai ,  LI, Haiyan ,  WU, Youbin ,  LIU, Jianghua ,  GUO, Yushen

IPC分类号： A61K9/20 ,  C07D215/24 ,  A61P35/00

摘要： Disclosed are a pharmaceutical composition containing nitroxoline, a nitroxoline tablet, a preparation method therefor, and a use thereof. The pharmaceutical composition comprises an active pharmaceutical ingredient and a pharmaceutically acceptable carrier, the active pharmaceutical ingredient being nitroxoline or a pharmaceutically acceptable salt thereof, and the active pharmaceutical ingredient having a particle size D 90 of 10-100µm. The pharmaceutical composition containing nitroxoline can be made into a nitroxoline tablet having an appropriate dissolution rate.