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    GENERATION OF A MESENCHYMAL STROMAL CELL BANK FROM THE POOLED MONONUCLEAR CELLS OF MULTIPLE BONE MARROW DONORS
    1.
    发明公开
    GENERATION OF A MESENCHYMAL STROMAL CELL BANK FROM THE POOLED MONONUCLEAR CELLS OF MULTIPLE BONE MARROW DONORS 审中-公开
    巨噬细胞集落刺激因子在骨髓单个核细胞中的表达

    公开(公告)号：EP3169772A1

    公开(公告)日：2017-05-24

    申请号：EP15736516.4

    申请日：2015-07-14

    申请人： Johann Wolfgang Goethe-Universität Frankfurt am Main ,  DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH

    发明人： BADER, Peter ,  KUCI, Selim ,  KUCI, Zyrafete ,  BÖNIG, Halvard

    IPC分类号： C12N5/0775

    摘要： The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared according to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disesase (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.

    摘要翻译： 本发明涉及改进的间充质基质细胞（MSC）制备物及其制备方法。 本发明提供了通过汇集多个不相关（第三方）骨髓供体的BM-MNC从骨髓单核细胞（BM-MNC）中分离MSC的新策略。 根据本发明的方法制造的MSC制剂的特征在于，与单个供体MSC制备物或由多个供体产生的单个MSC的库相比，其具有稳定的增殖能力和增加的免疫抑制潜力。 根据本发明制备的MSC特别适用于医疗应用，例如在造血干细胞移植受体，具有自身免疫性疾病的患者中治疗移植物抗宿主二糖酶（GvHD），以及作为再生医学中的基于细胞的疗法。