公开(公告)号：EP4212633A1

公开(公告)日：2023-07-19

申请号：EP22151440.9

申请日：2022-01-13

申请人： Johann-Wolfgang-Goethe-Universität Frankfurt am Main ,  Technische Universität Darmstadt

发明人： Schwalbe, Harald ,  Schlundt, Andreas ,  Göbel, Michael ,  Ciesek, Sandra ,  Weigand, Julia ,  Peter, Stephen ,  Ferner, Jan ,  Wacker, Anna ,  Richter, Christian ,  Sreeramulu, Sridhar ,  Ceylan, Betül ,  Adam, Jennifer ,  Töws, Sabrina ,  Scheffer, Ute

IPC分类号： C12Q1/6888 ,  G01N33/50 ,  A61K31/33

摘要： The present invention relates to a method for identifying a pharmaceutically active compound that modulates the function of a frame-shift pseudoknot element and/or modulates the function of a translation initiation-RNA element of an RNA virus in a mammalian cell. Furthermore, the present invention relates to a method to identify a second and further generation candidate compound with improved modulating properties, a screening system for identifying the pharmaceutically active compound, as well as compounds as identified, and methods of treating or preventing a viral infection caused by an RNA virus in a mammalian cell.