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    Diagnostic test kit and method for determination of chlamydial or gonococcal antigens using a microporous membrane
    2.
    发明公开
    Diagnostic test kit and method for determination of chlamydial or gonococcal antigens using a microporous membrane 失效
    诊断测试试剂盒和方法，用于衣原体或淋球菌抗原的测定，使用的微孔膜的。

    公开(公告)号：EP0363090A2

    公开(公告)日：1990-04-11

    申请号：EP89309943.2

    申请日：1989-09-29

    申请人： Johnson & Johnson Clinical Diagnostics, Inc.

    发明人： Mauck, John Charles, c/o EASTMAN KODAK Co.

    IPC分类号： G01N33/569 ,  G01N33/545

    CPC分类号： G01N33/56927 ,  G01N33/545 ,  G01N33/571 ,  Y10S435/871

    摘要： Antigens from chlamydial or gonococcal organisms in specimens containing whole blood, mucus or components thereof can be rapidly and sensitively determined using a polyamide microporous membrane which is coated with a surfactant. This determina­tion is accomplished by contacting extracted antigen with the coated polyamide microporous membrane which is substantially free of any particulate matter. The membrane has an average pore size of from 1 to 10 µmeter. Within 10 minutes of that contacting, antigen bound to the coated membrane is contacted with chlamydial or gonococcal antibody, respectively, so as to form an immunological complex on the membrane. The presence of the complex on the membrane in then determined as a measure of the amount of chlamydial or gonococcal antigen present in the specimen.

    摘要翻译： 从在含有全血，粘液或其组分标本衣原体或淋球菌抗原的生物体可以快速且灵敏地确定使用聚酰胺微孔膜的所有的涂有表面活性剂开采。 该确定是通过接触抗原提取与经涂覆的聚酰胺微孔膜的所有其基本上不含任何颗粒物质来实现的。 该膜具有以平均1至10亩计的孔径。 在10分钟内结合至涂覆的膜确实接触抗原与分别衣原体或淋球菌抗体，接触，以便形成上在膜上的免疫复合物。 该复合物在膜中然后确定性存在开采如衣原体或淋球菌抗原的存在于样品中的量的量度。

    Diagnostic test kit and method for determination of chlamydial antigen using a membrane having surface hydroxy groups
    6.
    发明公开
    Diagnostic test kit and method for determination of chlamydial antigen using a membrane having surface hydroxy groups 失效
    诊断测试试剂盒和方法，用于衣原体抗原的使用具有表面羟基的膜进行检测。

    公开(公告)号：EP0402993A2

    公开(公告)日：1990-12-19

    申请号：EP90201462.0

    申请日：1990-06-07

    申请人： Johnson & Johnson Clinical Diagnostics, Inc.

    发明人： Mauck, John Charles, c/o EASTMAN KODAK Co. ,  Boyer, Bradley Porter, c/o EASTMAN KODAK Co.

    IPC分类号： G01N33/569 ,  G01N33/545

    CPC分类号： G01N33/56927 ,  G01N33/54393 ,  G01N33/545

    摘要： Antigens from chlamydial organisms in specimens can be rapidly and sensitively determined using a polyamide microporous membrane which has surface hydroxy groups. This determination is accomplished by contacting extracted antigen with the polyamide microporous membrane for a sufficient time for the antigen to bind to the membrane. Antigen bound to the membrane is contacted with chlamydial antibody so as to form an immunological complex on the membrane. The presence of the complex on the membrane is then determined as a measure of the amount of chlamydial antigen present in the specimen. The use of this particular membrane improves reagent keeping and reduces background in the assay.

    摘要翻译： 从衣原体生物体抗原在试样可快速且灵敏地确定使用聚酰胺微孔膜其中具有表面羟基开采。 该确定是通过接触抗原提取用足够的时间对抗原结合至膜的聚酰胺微孔膜来实现的。 与膜结合的抗原与衣原体抗体接触，以便形成上在膜上的免疫复合物。 在膜的复合物的存在是确定的，然后作为开采存在于标本衣原体抗原的量的量度。 使用这种特殊的膜试剂的提高保持和在测定中减少背景。