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公开(公告)号：EP3609568A1
公开(公告)日：2020-02-19
申请号：EP18784254.7
申请日：2018-04-13
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公开(公告)号：EP4249006A2
公开(公告)日：2023-09-27
申请号：EP23185636.0
申请日：2012-10-26
IPC分类号： A61K51/12
摘要： Embodiments of the present invention provide for assessing the state of an 82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82 Rb, 82 Sr, or 85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82 Sr/ 82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82 Rb elution system. Further, in response to determining that a total volume of the fluid exceeds a limit threshold, elution is prevented until the generator is replaced with a new generator.
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公开(公告)号：EP3404663A1
公开(公告)日：2018-11-21
申请号：EP18167565.3
申请日：2018-04-16
CPC分类号： A61M5/007 , A61B6/037 , A61B6/481 , A61M5/1409 , A61M5/16813 , A61M2005/1403 , A61M2205/3327 , A61M2205/3334 , A61M2205/50 , G16H20/40
摘要： Provided are 82 Sr/ 82 Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual 82 Rb from the system downstream of the generator, and preferably deliver the removed residual 82 Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82 Sr/ 82 Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured.
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公开(公告)号：EP2893540A1
公开(公告)日：2015-07-15
申请号：EP12884208.5
申请日：2012-10-26
CPC分类号： G21G1/0005 , F04B49/065 , G05B15/02
摘要： Embodiments of the present invention provide for assessing the state of an
82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of
82 Rb,
82 Sr, or
85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a
82 Sr/
82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the
82 Rb elution system.-
公开(公告)号：EP4249006A3
公开(公告)日：2023-11-08
申请号：EP23185636.0
申请日：2012-10-26
摘要： Embodiments of the present invention provide for assessing the state of an 82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82 Rb, 82 Sr, or 85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82 Sr/ 82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82 Rb elution system. Further, in response to determining that a total volume of the fluid exceeds a limit threshold, elution is prevented until the generator is replaced with a new generator.
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公开(公告)号：EP3309796B1
公开(公告)日：2020-04-01
申请号：EP17200924.3
申请日：2012-10-26
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公开(公告)号：EP3309796A1
公开(公告)日：2018-04-18
申请号：EP17200924.3
申请日：2012-10-26
摘要： Embodiments of the present invention provide for assessing the state of an 82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82 Rb, 82 Sr, or 85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82 Sr/ 82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82 Rb elution system. Further, in response to determining that a total volume of the fluid exceeds a limit threshold, elution is prevented until the generator is replaced with a new generator.
摘要翻译： 本发明的实施例用于评估82Rb洗脱系统的状态。 在某些实施方案中，系统开始包括洗脱的评估，并且可以测量度量。 该度量可以是从发生器洗脱的流体中的82Rb，82Sr或85Sr的浓度，从发生器洗脱的流体的体积或流经系统的至少一部分的流体的压力 。 如果评估完成，则可根据评估结果在用户界面上生成输出结果，以推荐行动方案或无行动方案。 如果评估由于中断而未能成功完成，系统的82Sr / 82Rb发生器可能会停止运行，以防止用户在82Rb洗脱系统的质量控制机制周围进行最终运行。 此外，响应于确定流体的总体积超过极限阈值，防止洗脱，直到用新的发生器更换发生器。
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公开(公告)号：EP3696824A1
公开(公告)日：2020-08-19
申请号：EP20166557.7
申请日：2012-10-26
摘要： Embodiments of the present invention provide for assessing the state of an 82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82 Rb, 82 Sr, or 85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82 Sr/ 82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82 Rb elution system. Further, in response to determining that a total volume of the fluid exceeds a limit threshold, elution is prevented until the generator is replaced with a new generator.
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公开(公告)号：EP2893540B1
公开(公告)日：2018-01-10
申请号：EP12884208.5
申请日：2012-10-26
CPC分类号： G21G1/0005 , F04B49/065 , G05B15/02
摘要： Embodiments of the present invention provide for assessing the state of an 82 Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82 Rb, 82 Sr, or 85 Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82 Sr/ 82 Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82 Rb elution system. Further, in response to determining that a total volume of the fluid exceeds a limit threshold, elution is prevented until the generator is replaced with a new generator.
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公开(公告)号：EP3453422A1
公开(公告)日：2019-03-13
申请号：EP18179950.3
申请日：2007-02-26
发明人： DEKEMP, Robert A , KLEIN, Ran
摘要： A method of controlling an 82 Sr/ 82 Rb elution system having a generator valve for proportioning a flow of saline solution between an 82 Sr/ 82 Rb generator and a bypass line coupled to an outlet of the generator such that saline solution traversing the bypass line will merge with eluted saline solution emerging from the generator to provide an active saline solution. During each elution run, a plurality of successive concentration parameter values are obtained at predetermined intervals. Each concentration parameter value is indicative of a respective instantaneous activity concentration of the active saline solution. Respective error values between each concentration parameter value and a target activity concentration value of the elution run are computed. Error data based on a plurality of the computed error values is accumulated. Between successive elution runs, at least one performance parameter of the elution system is adjusted based on the accumulated error data.
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