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公开(公告)号：EP4316596A3
公开(公告)日：2024-04-17
申请号：EP23203704.4
申请日：2015-03-26
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00
CPC分类号： A61K2039/50520130101 , C07K2317/2420130101 , C07K2317/3420130101 , C07K2317/7320130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K16/22 , A61P35/00
摘要： The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
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2.发明公开
公开(公告)号：EP4218809A3
公开(公告)日：2023-08-09
申请号：EP22203233.6
申请日：2016-09-30
发明人： Wischhusen, Jörg , Haake, Markus , Dummer, Reinhard , Mehling, Matthias , Schäfer, Tina , Selle, Martina
IPC分类号： A61K39/395 , A61K31/00 , C07K16/22 , C07K16/28 , G01N33/574 , G01N33/50
摘要： The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
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3.发明公开
公开(公告)号：EP4218809A2
公开(公告)日：2023-08-02
申请号：EP22203233.6
申请日：2016-09-30
发明人： Wischhusen, Jörg , Haake, Markus , Dummer, Reinhard , Mehling, Matthias , Schäfer, Tina , Selle, Martina
IPC分类号： A61K39/395 , A61K31/00 , C07K16/22 , C07K16/28 , G01N33/574 , G01N33/50
摘要： The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
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公开(公告)号：EP4316596A2
公开(公告)日：2024-02-07
申请号：EP23203704.4
申请日：2015-03-26
IPC分类号： A61P35/00
摘要： The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
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