公开(公告)号：EP1710250B1

公开(公告)日：2009-04-15

申请号：EP05703875.4

申请日：2005-01-20

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： SHIBATA, Shinichi Chemo-Sero-Therapeutic Research Inst. ,  NAKASHIMA, Kazuyuki, ChemoSeroTherapeutic Res.Inst ,  TANABE, Tetsurou, Chemo-Sero-Therapeutic Res.Inst. ,  MIYATSU, Yoshinobu, ChemoSeroTherapeutic Res.Inst. ,  MIZOKAMI, Hiroshi, ChemoSeroTherapeutic Res. Inst.

IPC分类号： C07K1/30 ,  C07K14/76 ,  C12P21/02

CPC分类号： C07K1/30 ,  C07K14/765

摘要： A method of heating a human serum albumin solution containing foreign substances from host in the presence of divalent cation, such as calcium ion, magnesium ion, nickel ion, cobalt ion, iron ion or zinc ion to thereby effect selective coagulation of the foreign substances; and a human serum albumin of high purity obtained by the method.

公开(公告)号：EP1710250A1

公开(公告)日：2006-10-11

申请号：EP05703875.4

申请日：2005-01-20

申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： SHIBATA, S. Chemo-Sero-Theraputic Research Inst. ,  NAKASHIMA, Kazuyuki, ChemoSeroTherapeutic Res.Inst ,  TANABE, Tetsurou, Chemo-Sero-Therapeutic Res.Inst. ,  MIYATSU, Yoshinobu, ChemoSeroTherapeutic Res.Inst. ,  MIZOKAMI, Hiroshi, ChemoSeroTherapeutic Res. Inst.

IPC分类号： C07K1/30 ,  C07K14/76 ,  C12P21/02

CPC分类号： C07K1/30 ,  C07K14/765

摘要： The present invention herein discloses a method for purifying human serum albumin, which is characterized in that it comprises the steps of heat-treating a human serum albumin-containing solution including impurities originated from a host cell, in the presence of a divalent cation such as calcium ion, magnesium ion, nickel ion, cobalt ion, iron ion and zinc ion to thus selectively allow the impurities to undergo agglutination. The present invention also provides the highly purified human serum albumin prepared by the foregoing method.

摘要翻译： 这是在没有它包括以下步骤为特征的本发明中光盘松的方法用于纯化人血清白蛋白，所有热处理的含白蛋白的人血清溶液包括杂质源自二价阳离子的存在的宿主细胞：如 钙离子，镁离子，镍离子，钴离子，铁离子和锌离子，从而有选择地允许杂质经过凝集。 本发明因此提供了通过上述方法制备的高度纯化的人血清白蛋白。