公开(公告)号：EP2202306A1

公开(公告)日：2010-06-30

申请号：EP08837781.7

申请日：2008-10-08

申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

发明人： SOEJIMA, Kenji ,  IMAMURA, Takayuki ,  KAWAMURA, Ryoichi ,  NAKATAKE, Hiroshi ,  MAEYASHIKI, Arisa ,  TOGO, Hitomi

IPC分类号： C12N15/09 ,  A61K38/43 ,  A61P7/04 ,  C07K14/745 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02

CPC分类号： C12N9/6432 ,  A61K38/00 ,  C12Y304/21006

摘要： A Factor X (hereinafter referred to as "FX") with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

摘要翻译： 提供了具有高活性的因子X（以下称为“FX”）。 本发明涉及一种有效制备重组双链FX的方法，该方法包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达， 通过所述方法获得的没有糖基化的FX。