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1.发明公开
公开(公告)号：EP1726649A2
公开(公告)日：2006-11-29
申请号：EP06010000.5
申请日：2002-05-10
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute , HISAMITSU PHARMACEUTICAL CO., INC.
发明人： HIRASHIMA, Masaki c/o Juridical Foundation The , NARUSE, Takeshi c/o Juridical Foundation The , MAEDA, Hiroaki c/o Juridical Foundation The , NOZAKI, Chikateru c/o Juridical Foundation The , GOTO, Takeshi c/o Hisamitsu Pharm. Co., Inc. , AKIYAMA, Katsuhiko c/o Hisamitsu Pharm. Co., Inc. , HATTORI, Wataru c/o Hisamitsu Pharm. Co., Inc.
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
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2.发明公开
公开(公告)号：EP1726649A3
公开(公告)日：2007-03-28
申请号：EP06010000.5
申请日：2002-05-10
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute , HISAMITSU PHARMACEUTICAL CO., INC.
发明人： HIRASHIMA, Masaki c/o Juridical Foundation The , NARUSE, Takeshi c/o Juridical Foundation The , MAEDA, Hiroaki c/o Juridical Foundation The , NOZAKI, Chikateru c/o Juridical Foundation The , GOTO, Takeshi c/o Hisamitsu Pharm. Co., Inc. , AKIYAMA, Katsuhiko c/o Hisamitsu Pharm. Co., Inc. , HATTORI, Wataru c/o Hisamitsu Pharm. Co., Inc.
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
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