摘要:
Efficient and economical processes for producing azetidine-2-carboxylic acid and intermediates thereof on an industrial scale. Azetidine-2-carboxylic acid of structural formula (5) is produced by reducing a 4-oxo-2-azetidinecarboxylic acid derivative of general formula (1) to form azetidine-2-methanol of structural formula (2), treating this compound with an amino-protecting agent to form an N-protected azetidine-2-methanol of general formula (3), treating this compound with an oxidizing agent to form an N-protected azetidine-2-carboxylic acid of general formula (4), and removing the amino-protecting group.