PROCESSES FOR PRODUCING AZETIDINE-2-CARBOXYLIC ACID AND INTERMEDIATES THEREOF
    2.
    发明公开
    PROCESSES FOR PRODUCING AZETIDINE-2-CARBOXYLIC ACID AND INTERMEDIATES THEREOF 失效
    用于生产氮杂环丁烷-2-羧酸和其中间体

    公开(公告)号:EP0992491A4

    公开(公告)日:2000-07-19

    申请号:EP98917669

    申请日:1998-04-24

    申请人: KANEKA CORP

    IPC分类号: C07D205/04

    CPC分类号: C07D205/04 Y02P20/55

    摘要: Efficient and economical processes for producing azetidine-2-carboxylic acid and intermediates thereof on an industrial scale. Azetidine-2-carboxylic acid of structural formula (5) is produced by reducing a 4-oxo-2-azetidinecarboxylic acid derivative of general formula (1) to form azetidine-2-methanol of structural formula (2), treating this compound with an amino-protecting agent to form an N-protected azetidine-2-methanol of general formula (3), treating this compound with an oxidizing agent to form an N-protected azetidine-2-carboxylic acid of general formula (4), and removing the amino-protecting group.