专利检索 ap:("KANEKA CORPORATION") AND inv:"KINOSHITA, Koichi, c/o KANEKA CORPORATION" 第 1 页

1.

发明公开
PROCESSES FOR PRODUCING OPTICALLY ACTIVE 2-THIOMETHYL-3-PHENYLPROPIONIC ACID DERIVATIVE AND FOR PRODUCING INTERMEDIATE THEREFOR 审中-公开
标题翻译：方法用于制造光学assets2甲基硫-3-PHENYLPROPIONSÄUREDERIVATS和，产生中间THEREFOR

公开(公告)号：EP1577310A1

公开(公告)日：2005-09-21

申请号：EP03778791.8

申请日：2003-12-10

申请人： KANEKA CORPORATION

发明人： OHISHI, Takahiro, c/o KANEKA CORPORATION , MORI, Kohei, c/o KANEKA CORPORATION , KINOSHITA, Koichi, c/o KANEKA CORPORATION , MAEHARA, Katsuji, c/o KANEKA CORPORATION , KAWASAKI, Hiroaki, c/o KANEKA CORPORATION , NAGASHIMA, Nobuo, c/o KANEKA CORPORATION , FUSE, Yoshihide, c/o KANEKA CORPORATION

IPC分类号： C07D407/06 , C07D317/60 , C07D305/12

CPC分类号： C07D305/12 , C07C319/14 , C07D317/60 , C07D407/06 , C07C323/56

摘要： The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active β-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.