专利检索 ap:("KAO CORPORATION") AND inv:"FUKUNAGA, Kyoko" 第 1 页

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发明授权
NOVEL GALACTOSYLCERAMIDE ANALOGS AND BETA-GLUCOCEREBROSIDASE ACTIVATORS,EXTERNAL SKIN PREPARATIONS AND METHOD OF ACTIVATING BETA-GLUCOCEREBROSIDASE USING THE ANALOGS 有权
标题翻译：新GALACTOSYLCERAMIDANALOGA和BETA GLUCOCEREBROSIDASEAKTIVATOREN，外用制剂激活BETA脂酶皮肤及其使用方法类似物

公开(公告)号：EP1408045B1

公开(公告)日：2009-05-27

申请号：EP02743752.4

申请日：2002-06-27

申请人： KAO CORPORATION

发明人： UEMATSU, Rie , NAKAJIMA, Fumio , YOSHIDA, Masahiro , FUKUNAGA, Kyoko , HARA, Mariko , INOUE, Shintaro , NISHIMURA, Shinichiro

IPC分类号： C07H15/14 , A61K8/00 , A61K31/7028 , A61P17/16 , A61P43/00

CPC分类号： C07H15/14 , A61K8/602 , A61Q19/00

摘要： Galactosylceramide analogs represented by the following general formula (1) or (2): (1) (2) wherein X and Y represent each S or O; R 1 and R 2 represent each C 9−35 alkyl or alkenyl; and R 3 represents C 2−30 alkyl or alkenyl. Easily available β−glucocerebrosidase activators, external skin preparations and a method of activating β−glucocerebrosidase whereby the formation of a horny layer penetration barrier can be improved through the activation of β−glucocerebrosidase and, as result, it is expected that skin roughness can be ameliorated.