公开(公告)号：EP3517113A1

公开(公告)日：2019-07-31

申请号：EP17852425.2

申请日：2017-09-22

申请人： KBP Biosciences Co., Ltd.

发明人： HUANG, Zhenhua ,  GUO, Xiaocui

IPC分类号： A61K31/4745 ,  A61K47/00 ,  A61K9/00 ,  A61P13/12

摘要： Provided are a pharmaceutical composition comprising a mineralocorticoid receptor antagonist and use thereof. When the pharmaceutical composition is orally administered to a patient having chronic kidney disease in need thereof, the effective and safe AUC ranges from 188 ng ∗ h/mL to 3173 ng ∗ h/mL, with bioavailability of 50% or more in mammals. When the pharmaceutical composition is orally administered at a daily dose of 0.1 to 1.0 mg to treat chronic kidney disease, the AUC is controlled at a safe and effective level.