公开(公告)号：EP0947202A2

公开(公告)日：1999-10-06

申请号：EP99201853.1

申请日：1993-09-23

申请人： KEELE UNIVERSITY

发明人： Al-Shamkhani, Aymen, Sir William Dunn School Path. ,  Duncan, Ruth

IPC分类号： A61K47/48

CPC分类号： C08B37/0084 ,  A61K47/61

摘要： A therapeutically-useful conjugate comprises an alginate polymeric carrier and a therapeutically-active bioactive agent connected covalently via a biodegradable spacer linkage interposed therebetween which enables the bioactive agent to be progressively released, under predetermined environmental conditions, following administration to a mammal in the course of therapy. The conjugate is effective for delivering bioactive agents to targets existing in low-pH environments, either at the target surface or in the target interior.

摘要翻译： 治疗上有用的缀合物包含藻酸盐聚合物载体和治疗活性生物活性剂，其通过介于其间的可生物降解的间隔连接体共价连接，其使生物活性剂在预定的环境条件下，在给予哺乳动物的过程中逐渐释放 治疗。 该缀合物有效地将生物活性剂递送到目标表面或目标内部的低pH环境中存在的目标。