公开(公告)号：EP1587505A4

公开(公告)日：2007-10-31

申请号：EP03799944

申请日：2003-12-15

申请人： KIMBERLY CLARK CO

发明人： MALIK SOHAIL

IPC分类号： A61K31/12 ,  A61K31/19 ,  A61K31/194 ,  A61K31/215 ,  A61K31/365 ,  A61K31/50 ,  A61K31/519 ,  A61K31/60 ,  A61K31/70 ,  A61P17/02 ,  A61Q19/00

CPC分类号： A61K31/60 ,  A61K31/19 ,  A61K31/194 ,  A61K31/365 ,  A61K31/519 ,  A61K31/70 ,  A61K2300/00

摘要： The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and/or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.

公开(公告)号：EP1581252A4

公开(公告)日：2007-10-31

申请号：EP03776343

申请日：2003-10-09

申请人： KIMBERLY CLARK CO

发明人： MALIK SOHAIL

IPC分类号： A61K31/12 ,  A61K31/19 ,  A61K31/194 ,  A61K31/215 ,  A61K31/365 ,  A61K31/50 ,  A61K31/519 ,  A61K31/52 ,  A61K31/60 ,  A61K31/70 ,  A61P17/02 ,  A61Q19/00

CPC分类号： A61K31/52 ,  A61K31/19 ,  A61K31/194 ,  A61K31/365 ,  A61K31/519 ,  A61K31/60 ,  A61K31/70 ,  A61K2300/00

摘要： The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.

公开(公告)号：EP1423515A4

公开(公告)日：2008-02-27

申请号：EP02759388

申请日：2002-08-15

申请人： KIMBERLY CLARK CO

发明人： QUIRK STEPHEN ,  MALIK SOHAIL ,  VILLANUEVA JULIE M

IPC分类号： A61K38/00 ,  A61K38/55 ,  A61P17/00 ,  C07K14/00 ,  C07K14/50 ,  C07K14/81 ,  C12N9/99

CPC分类号： C07K14/8146 ,  A61K38/00

摘要： The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

公开(公告)号：EP1578780A4

公开(公告)日：2008-05-14

申请号：EP03789843

申请日：2003-11-18

申请人： KIMBERLY CLARK CO

发明人： MALIK SOHAIL ,  QUIRK STEPHEN

IPC分类号： A61K8/64 ,  A61K38/48 ,  A61Q11/00 ,  C12N9/64 ,  A61K38/00 ,  A61K38/04

CPC分类号： A61K38/4886 ,  A61K8/64 ,  A61Q11/00