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    Succinic acid compounds
    5.
    发明公开
    Succinic acid compounds 失效
    Bernsteinsäurederivaten。

    公开(公告)号：EP0507534A1

    公开(公告)日：1992-10-07

    申请号：EP92302786.6

    申请日：1992-03-30

    申请人： KISSEI PHARMACEUTICAL CO., LTD.

    发明人： Sato, Fumiyasu ,  Tsubaki, Atsushi ,  Hokari, Hiroshi ,  Tanaka, Nobuyuki ,  Saito, Masaru, Kissei Dai-san Seiyuryo ,  Akahane, Kenji ,  Kobayashi, Michihiro

    IPC分类号： C07D209/08 ,  C07D209/44 ,  C07D217/06 ,  C07D409/06 ,  A61K31/395

    CPC分类号： C07D409/06 ,  C07D209/08 ,  C07D209/44 ,  C07D217/06

    摘要： Succinic acid compounds of the formula:

    wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R 1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.

    摘要翻译： 具有下式的琥珀酸化合物：其中A表示杂环基，3至8元环烷基或苯基，其可以具有一个或多个选自以下的取代基：卤素原子，具有 1至6个碳原子和1至6个碳原子的低级烷氧基; B表示可以具有1或2个不饱和键的双环氨基，条件是B与氮原子上的羰基的碳原子键合; R表示氢原子或彼此结合形成化学键; R 1表示氢原子，碳原子数1〜6的低级烷基或碳原子数7〜10的芳烷基。 当存在不对称碳原子时，其对映异构体和其外消旋混合物; 当存在几何异构体时，每种几何异构体，其异构体，其Z-异构体，其顺式异构体和其反式异构体; 和其药学上可接受的盐，增强胰岛素分泌并具有降血糖活性，因此可用于治疗糖尿病。

    Isatin derivatives, compositions containing the same, and the use thereof for ulcer diseases
    6.
    发明公开
    Isatin derivatives, compositions containing the same, and the use thereof for ulcer diseases 失效
    Isatinderivate，diese enthaltende Zusammensetzungen und deren Anwendung gegenGeschwüre。

    公开(公告)号：EP0205299A2

    公开(公告)日：1986-12-17

    申请号：EP86304195.0

    申请日：1986-06-03

    申请人： Kissei Pharmaceutical Co Ltd

    发明人： Kobayashi, Michihiro ,  Tsukamoto, Tsutomu ,  Kitazawa, Makio ,  Yamomoto, Ryoji ,  Akahane, Masuo ,  Nakano, Yasushi

    IPC分类号： C07D209/40 ,  C07D209/38 ,  A61K31/40

    CPC分类号： C07D209/40

    摘要： An isatin derivative represented by the general formula:
    wherein R' represents a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or a cycloalkyl group, R 2 represents a branched-chain alkyl group, R 3 represents a hydrogen atom, an alkyl group, an aralkyl group or a cycloalkyl group, R represents a halogen atom, an alkyl group, an alkoxy group, an amino group, an acylamino group or an alkoxycarbonyl group, n is an integer of from 0 to 2, and Y represents an alkylene group; or a pharmaceutically acceptable saltthereof.
    The isatin derivatives and the pharmaceutically acceptable salts thereof possess anti-ulcer activities and thus are useful for prophylaxis and treatment of ulcer diseases in the digestive tract.

    摘要翻译： 由以下通式表示的靛红衍生物：其中R 1表示氢原子，烷基，芳基，芳烷基或环烷基，R 2表示支链烷基， R 3表示氢原子，烷基，芳烷基或环烷基，R表示卤素原子，烷基，烷氧基，氨基，酰氨基或烷氧基羰基，n为 0〜2的整数，Y表示亚烷基。 或其药学上可接受的盐。 靛红衍生物及其药学上可接受的盐具有抗溃疡活性，因此可用于预防和治疗消化道溃疡疾病。