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1.发明公开DIAGNOSTIC KIT FOR DIAGNOSING DISORDERS OR DISEASES RELATED TO ABNORMAL PROTEIN AGGREGATION OR MISFOLDING OF PROTEIN USING DISSOLUTION OF PROTEIN AGGREGATES 审中-公开对于病症或疾病的与异常蛋白聚集或错折叠有关通过拆分蛋白质聚集体的诊断的诊断试剂盒
公开(公告)号：EP2990801A4
公开(公告)日：2016-11-30
申请号：EP14788047
申请日：2014-04-25
Applicant: KOREA INST SCI & TECH
Inventor： KIM YOUNG SOO , KIM DONG JIN , KIM HYE YUN , CHO SOO MIN , LEE SEJIN , KIM HYUNJIN , KIM TAE SONG , HWANG KYOSEON , ROH JEE HOON , KOH JAE-YOUNG
CPC classification number: G01N33/6893 , G01N33/6827 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of ²-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.
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2.发明公开PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE IMPAIRMENT-RELATED DISEASE COMPRISING MORPHOLINE OR PIPERAZINE BASED COMPOUNDS, AND DONEPEZIL 审中-公开用于预防的药物组合物和疾病治疗用吗啉或PIPERAZINBASIERTEN化合物多奈哌齐认知故障ASSOCIATED
公开(公告)号：EP3013346A4
公开(公告)日：2016-11-02
申请号：EP14817212
申请日：2014-06-26
Applicant: KOREA INST SCI & TECH
Inventor： KIM DONG JIN , KIM YOUNG SOO , KIM HYE YUN , KIM HYUN JIN
IPC: A61K31/5375 , A61K31/445 , A61K31/4965 , A61P25/16
CPC classification number: C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
Abstract: Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
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3.发明公开STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开STYRYLBENZOFURANDERIVATE地层β淀粉样原纤维和方法，用于生产抑制剂
公开(公告)号：EP2291364A4
公开(公告)日：2011-08-17
申请号：EP09762685
申请日：2009-06-12
Applicant: KOREA INST SCI & TECH , HANMI HOLDINGS CO LTD
Inventor： KIM DONG JIN , YOO KYUNG HO , BYUN JI HUN , KIM YOUNGSOO , KIM HYE YUN , LEE GWAN SUN , KIM MAENG SUP , AHN YOUNG GIL , LEE JI HOON , LEE MYOUNG-HWAN , HWANG HANA , RYU JIYEON
IPC: C07D307/78 , A61K31/343 , A61P25/28
CPC classification number: C07D307/81 , C07D307/80
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