-
1.发明公开NOVEL ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 失效新的抗病毒2.4嘧啶二酮衍生物及其制造方法
公开(公告)号：EP0736015A1
公开(公告)日：1996-10-09
申请号：EP95903455.0
申请日：1994-12-20
发明人： SON, Jong, Chan , LEE, Ill, Young , BAE, Byung, Il , HAN, Jeong, Sik , CHOI, Joong, Kwon , CHAE, Yung, Bok
CPC分类号： C07D239/54 , C07D239/60
摘要： Novel 2,4-pyrimidinedione compounds, and pharmaceutically acceptable salts thereof which possess good antiviral activities, and specifically represented by formula (I) wherein: R1 represents an unsubstituted or substituted alkyl group represented by CH¿2?CH=CR?5R6¿ or an unsubstituted or substituted propargyl group represented by CH¿2?C CR?7¿ wherein R?5, R6 and R7¿ are each independently a hydrogen atom; a methyl group optionally substituted with a halogen atom, or a C¿1-10? carbonyloxy, hydroxy, azido, cyano, optionally substituted amino, optionally substituted phosphonyl, optionally substituted phenyl, C3-10 heteroaryl, C1-3 alkoxy or benzyloxy radical; a C2-10 alkyl or alkenyl group; a cyclopropyl group; an optionally substituted phenyl group; a C3-10 heteroaryl group; a C1-10 ester group; or an optionally substituted C1-10 alkylamide group; R?2¿ represents a halogen atom, an optionally substituted C¿1-5? alkyl, C3-6 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl group or a benzyl group; R?3 and R4¿ represent independently a hydrogen or halogen atom, or a hydroxy, C¿1-3? alkyl, fluoromethyl, C1-3 alkoxy, amino, C2-6 alkylester or C2-7 alkylamide group; A represents an oxygen or sulfur atom; Z represents an oxygen or sulfur atom; a carbonyl group; an amino group; or a methylene group optionally substituted with at least one selected from the group consisting of a halogen atom, and a cyano, hydroxy, azido, amino, C1-3 alkylamide, C1-4 ester, and nitro groups.
-
2.发明授权ANTIVIRAL 2,4-PYRIMIDINDIONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 失效抗病毒2.4嘧啶二酮衍生物和工艺及其
公开(公告)号：EP0736015B1
公开(公告)日：2001-03-07
申请号：EP95903455.4
申请日：1994-12-20
发明人： SON, Jong, Chan , LEE, Ill, Young , BAE, Byung, Il , HAN, Jeong, Sik , CHOI, Joong, Kwon , CHAE, Yung, Bok
IPC分类号： C07D239/60 , C07D239/54 , A61K31/505
CPC分类号： C07D239/54 , C07D239/60
摘要： Novel 2,4-pyrimidinedione compounds, and pharmaceutically acceptable salts thereof which possess good antiviral activities, and specifically represented by formula (I) wherein: R1 represents an unsubstituted or substituted alkyl group represented by CH¿2?CH=CR?5R6¿ or an unsubstituted or substituted propargyl group represented by CH¿2?C CR?7¿ wherein R?5, R6 and R7¿ are each independently a hydrogen atom; a methyl group optionally substituted with a halogen atom, or a C¿1-10? carbonyloxy, hydroxy, azido, cyano, optionally substituted amino, optionally substituted phosphonyl, optionally substituted phenyl, C3-10 heteroaryl, C1-3 alkoxy or benzyloxy radical; a C2-10 alkyl or alkenyl group; a cyclopropyl group; an optionally substituted phenyl group; a C3-10 heteroaryl group; a C1-10 ester group; or an optionally substituted C1-10 alkylamide group; R?2¿ represents a halogen atom, an optionally substituted C¿1-5? alkyl, C3-6 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl group or a benzyl group; R?3 and R4¿ represent independently a hydrogen or halogen atom, or a hydroxy, C¿1-3? alkyl, fluoromethyl, C1-3 alkoxy, amino, C2-6 alkylester or C2-7 alkylamide group; A represents an oxygen or sulfur atom; Z represents an oxygen or sulfur atom; a carbonyl group; an amino group; or a methylene group optionally substituted with at least one selected from the group consisting of a halogen atom, and a cyano, hydroxy, azido, amino, C1-3 alkylamide, C1-4 ester, and nitro groups.
-
搜索结果
2 条记录 (耗时 0.01 秒)
