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    FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    1.
    发明公开
    FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
    呋喃甲硼烷基胍衍生物，它们的制备和含有它们的药物组合物

    公开(公告)号：EP1697335A1

    公开(公告)日：2006-09-06

    申请号：EP04808564.1

    申请日：2004-12-24

    申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  Yuyu Inc.

    发明人： YI, Kyu Yang ,  LEE, Sun Kyung ,  KIM, Nak Jeong ,  SUH, Jee Hee ,  HWANG, Soon Hee ,  LEE, Byung Ho ,  SEO, Ho Won ,  HWANG, Sun Kyung ,  YOO, Sung Eun ,  LEE, Kyung Hee

    IPC分类号： C07D307/68

    CPC分类号： C07D307/68

    摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/ reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be ef­fectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

    摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠 - 氢交换体亚型1），其有助于恢复由缺血/再灌注损伤的心脏功能并降低心肌梗塞率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于心肌梗塞，心律失常，心绞痛等缺血性心脏病的预防和治疗，也是用于包括溶栓剂在内的再灌注治疗中的心脏保护剂的有希望的候选者 或心脏手术包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等。