公开(公告)号：EP1801231A4

公开(公告)日：2008-05-21

申请号：EP05783483

申请日：2005-09-14

申请人： KOWA CO ,  TAKEUCHI TSUTOMU ,  TSUZAKA KENSEI ,  YOSHIMOTO KEIKO

发明人： TAKEUCHI TSUTOMU ,  TSUZAKA KENSEI ,  YOSHIMOTO KEIKO

IPC分类号： C12Q1/02 ,  A61K31/341 ,  A61K39/395 ,  A61P43/00 ,  C12Q1/68

CPC分类号： C07K16/2875 ,  A61K31/341 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/6863 ,  G01N2500/00

摘要： A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.