公开(公告)号：EP3031442A4

公开(公告)日：2017-02-08

申请号：EP14834295

申请日：2014-08-04

申请人： KURARAY NORITAKE DENTAL INC

发明人： HATANAKA KENJI ,  ISHIHARA SHUMEI

IPC分类号： A61K6/033 ,  A61K6/00 ,  A61K6/027 ,  A61K6/04 ,  A61K8/02 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61Q11/00

CPC分类号： A61K6/007 ,  A61K6/0008 ,  A61K6/0038 ,  A61K6/0082 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/24 ,  A61Q11/00

摘要： The present invention provides a dentinal tubule sealing material excellent in durability of dentinal tubule sealing performance (acid resistance) and also in storage stability. The present invention relates to a dentinal tubule sealing material including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and a non-aqueous dispersant (D), the dentinal tubule sealing material including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).

公开(公告)号：EP3031441A4

公开(公告)日：2017-02-08

申请号：EP14834444

申请日：2014-08-04

申请人： KURARAY NORITAKE DENTAL INC

发明人： HATANAKA KENJI ,  ISHIHARA SHUMEI

IPC分类号： A61K6/033 ,  A61K6/00 ,  A61K6/027 ,  A61K6/04 ,  A61K8/02 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61L27/12 ,  A61Q11/00

CPC分类号： A61K33/42 ,  A61K6/00 ,  A61K6/0017 ,  A61K6/0038 ,  A61K6/0085 ,  A61K6/033 ,  A61K6/0643 ,  A61K33/10 ,  A61L27/12 ,  A61L2430/02 ,  A61L2430/12 ,  A61M2025/0019

摘要： The present invention provides a curable calcium phosphate composition for biological hard tissue repair that yields a cured product excellent in durability in a wet environment such as in a body or an oral cavity. The present invention relates to a curable calcium phosphate composition for biological hard tissue repair, including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and water (D), the curable calcium phosphate composition including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).

摘要翻译： 本发明提供一种用于生物硬组织修复的可固化磷酸钙组合物，其产生在诸如身体或口腔的湿润环境中耐久性优异的固化产物。 本发明涉及一种用于生物硬组织修复的可固化磷酸钙组合物，包括磷酸四钙颗粒（A），磷酸氢钙颗粒（B），碳酸钙颗粒（C）和水（D），可固化的磷酸钙组合物 包括5至75重量份的磷酸四钙颗粒（A），10至70重量份的磷酸氢钙颗粒（B）和2至50重量份的碳酸钙颗粒（C）/ 100份 （A），磷酸氢钙颗粒（B）和碳酸钙颗粒（C）的总重量。

公开(公告)号：EP2979679A4

公开(公告)日：2016-08-31

申请号：EP14773187

申请日：2014-03-25

申请人： KURARAY NORITAKE DENTAL INC

发明人： KAWASHIMA MITSUNOBU ,  TAKEI MITSURU ,  NISHIGAKI NAOKI ,  ISHIHARA SHUMEI ,  HATANAKA KENJI ,  ISHINO HIROSHIGE ,  TSUJI AKIKO

IPC分类号： A61K6/08 ,  A61K6/00 ,  A61K6/097

CPC分类号： A61K6/083 ,  A61K6/08 ,  A61K6/0835 ,  A61K6/097 ,  A61K6/0017 ,  C08L5/00 ,  A61K6/0023 ,  C08L1/00

公开(公告)号：EP2902006A4

公开(公告)日：2016-04-20

申请号：EP13840214

申请日：2013-09-26

申请人： KURARAY NORITAKE DENTAL INC

发明人： ISHIHARA SHUMEI ,  HATANAKA KENJI

IPC分类号： A61K6/027 ,  A61K6/033 ,  A61K6/06 ,  A61K6/083

CPC分类号： A61K6/0082 ,  A61K6/0088

公开(公告)号：EP3213737A4

公开(公告)日：2018-07-04

申请号：EP15854470

申请日：2015-10-29

申请人： KURARAY NORITAKE DENTAL INC

发明人： HATANAKA KENJI ,  ISHIHARA SHUMEI

IPC分类号： A61K6/033 ,  A61K6/00 ,  A61K6/06 ,  A61Q11/00

CPC分类号： A61K6/033 ,  A61K6/0008 ,  A61K6/0643 ,  A61K8/24 ,  A61Q11/00

摘要： The present invention provides a dentinal tubule occlusion material excellent in terms of initial degree of dentinal tubule occlusion, resistance of dentinal tubule occlusion to acids, handling properties, and storage stability. The present invention relates to an one-pack type dentinal tubule occlusion material comprising fluorapatite particles (A) having an average particle diameter of 0.6 to 10 µm, inorganic particles (B) having an average particle diameter of 0.6 to 10 µm and reactive with water to form apatite, and a non-aqueous dispersant (C).

公开(公告)号：EP3053570A4

公开(公告)日：2017-05-24

申请号：EP14848283

申请日：2014-09-29

申请人： KURARAY NORITAKE DENTAL INC

发明人： ISHIHARA SHUMEI ,  HATANAKA KENJI

IPC分类号： A61K6/02 ,  A61K6/00 ,  A61K8/24 ,  A61Q11/00

CPC分类号： A61K6/033 ,  A61K6/0008 ,  A61K6/0017 ,  A61K6/02 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/24 ,  A61K8/345 ,  A61K8/86 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/5922 ,  A61K2800/651 ,  A61Q11/00

摘要： A dentinal tubule sealant including apatite particles (A) having an average particle diameter of 500 nm or less, a filler (B) having an average particle diameter of 1 to 10 µm, and a dispersant (C), wherein the weight ratio (A/B) of the apatite particles (A) to the filler (B) is 0.05 to 15, the dentinal tubule sealant contains 15 to 95 parts by weight of the dispersant (C) relative to 100 parts by weight in total of the apatite particles (A) and the filler (B), and the total amount of the apatite particles (A), the filler (B), and the dispersant (C) is 85 parts by weight or more relative to 100 parts by weight of the dentinal tubule sealant. There is thereby provided a dentinal tubule sealant excelling in dentinal tubule sealability immediately after treatment, durability of dentinal tubule sealing, ease of operation, and storage stability.

摘要翻译： 一种牙本质小管封闭剂，其特征在于，含有平均粒径为500nm以下的磷灰石粒子（A），平均粒径为1〜10μm的填充剂（B）和分散剂（C），其中， / B）为0.05〜15时，相对于磷灰石粒子的合计100重量份，所述分散剂（C）为15〜95重量份时，所述牙本质小管封闭剂 （A）和填充剂（B）的总重量，相对于牙本质100重量份，磷灰石颗粒（A），填充剂（B）和分散剂（C）的总量为85重量份以上 小管密封胶。 由此提供了一种牙本质小管密封剂，其在治疗后立即具有优异的牙本质小管密封性，牙本质小管密封的耐久性，易于操作和储存稳定性。

公开(公告)号：EP2626058A4

公开(公告)日：2015-01-07

申请号：EP11830599

申请日：2011-09-30

申请人： KURARAY NORITAKE DENTAL INC

发明人： HASHIMOTO TADASHI ,  OSHITA MIZUKO ,  ISHIHARA SHUMEI

IPC分类号： A61K6/033

CPC分类号： A61K8/24 ,  A61K6/0017 ,  A61K6/033 ,  A61K6/0643 ,  A61K8/19 ,  A61K2800/59 ,  A61Q11/00

摘要： A dentinal tubule sealant comprises poorly-soluble calcium phosphate particles (A), a phosphorus-free calcium compound (B), and water (C), wherein the particles (A) are at least one member selected from the group consisting of dicalcium phosphate anhydrous [CaHPO 4 ] particles, ±-tricalcium phosphate [±-Ca 3 (PO 4 ) 2 ] particles, ²-tricalcium phosphate [²-Ca 3 (PO 4 ) 2 ] particles, amorphous calcium phosphate [Ca 3 (PO 4 ) 2 €¢nH 2 O] particles, calcium pyrophosphate [Ca 2 P 2 O 7 ] particles, calcium pyrophosphate dihydrate [Ca 2 P 2 O 7 €¢2H 2 O] particles, octacalcium phosphate pentahydrate [Ca 8 H 2 (PO 4 ) 6 €¢5H 2 O] particles, and dicalcium phosphate dihydrate [CaHPO 4 €¢2H 2 O] particles, and the dentinal tubule sealant contains 30 to 76% by weight of the particles (A), 0.001 to 4% by weight of the compound (B), and 23 to 69% by weight of the water (C). Thus, there is provided a dentinal tubule sealant capable of sealing dentinal tubules of an exposed dentin and also remineralizing the surrounding dentin after the sealing.