公开(公告)号：EP0497978A4

公开(公告)日：1993-03-10

申请号：EP90915817

申请日：1990-10-24

申请人： KYOTO PHARMACEUTICAL INDUSTRIES, LTD.

发明人： MURO, HIROYUKI 283, BIWA-CHO OHAMA ,  KASAI, MASAYASU TAKANOHARA-ABAN B-408 ,  HATANO, SATORU 6-1-403, KITAKAWARA 2-CHOME ,  NISHIMURA, KEN-ICHI 14, YAMANOUCHI MIYAMAE-CHO ,  NISHIZAWA, SUSUMU HAIMU-FUSHIMI C-610 ,  KAKEYA, NOBUHARU 10-16, TAKADAI 3-CHOME

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： Cephalosporin compounds represented by general formula (I), pharmacologically acceptable addition salts thereof, method for the production thereof, and medicinal uses thereof, wherein R1 represents hydrogen or lower alkyl, and R2 represents 1-alkanoyloxyalkyl or 1-alkoxycarbonyloxy-alkyl. These compounds and salts not only can be readily absorbed through the digestive tract to exhibit wide antibacterial activities in vivo in the form of the hydrolyzates thereof, but also have remarkable sweetness 10 to 400 times as high as that of sucrose. Therefore they are useful in preventing and treating infectious diseases by oral administration.