公开(公告)号：EP1227097A1

公开(公告)日：2002-07-31

申请号：EP00969907.5

申请日：2000-10-19

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： AKAMA, Tsutomu ,  ASAI, Akira Pharm. Res. Kyowa Hakko Kogyo Co. Ltd ,  AGATSUMA, Tsutomu Tokyo Res. Kyowa Hakko Kogyo Ltd ,  NARA, Shinji Pharm. Res. Kyowa Hakko Kogyo Co.Ltd ,  YAMASHITA, Yoshinori Kyowa Hakko Kogyo Co. Ltd ,  MIZUKAMI, Tamio Kyowa Hakko Kogyo Co.Ltd ,  IKEDA, Shun-ichi Sakai KyowaHakko Kogyo Co. Ltd ,  SAITOH, Yutaka Fuji Kyowa Hakko Kogyo Co., Ltd ,  KANDA, Yutaka Pharm. R. Kyowa Hakko Kogyo Co. Ltd

IPC分类号： C07D487/04 ,  C07D487/14 ,  C07D487/16 ,  C07D491/147 ,  C07D491/16 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4439 ,  A61P31/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D487/14 ,  C07D491/14

摘要： UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I):
wherein R 1 represents hydrogen, lower alkyl, etc.; R 2 represents hydrogen, or is combined with R 3 to represent a bond, etc., or is combined with R 4 to represent -O(C=O)-, etc.; R 3 represents hydrogen, etc., or is combined with R 2 to represent a bond, etc.; R 4 represents hydrogen, etc., or is combined with R 2 to represent -(C=O)O-, etc.; R 5 represents hydrogen or is combined with R 6 to represent a bond; R 6 represents hydrogen, etc., or is combined with R 5 to represent a bond; R 7 represents hydrogen or is combined with R 8 to represent =O; R 8 represents hydroxy or is combined with R 7 to represent =O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

摘要翻译： 由式（I）表示的具有抗肿瘤活性或抗菌活性的UCS 1025衍生物：其中R 1表示氢，低级烷基等; R 2表示氢，或与R 3结合以表示键等，或与R 4结合以表示-O（C = O） - 等; R 3表示氢等，或与R 2结合以代表键等; R 4表示氢等，或与R 2结合代表 - （C = O）O-等; R 5表示氢或与R 6结合以表示键; R 6表示氢等，或与R 5结合以表示键; R 7代表氢或与R 8结合代表= O; R 8表示羟基或与R 7结合代表= O; ----表示单键或双键，a表示单键（键合有两个碳原子结合形成单键）或氧原子，或其药学上可接受的盐。