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    [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
    1.
    发明公开
    [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES 有权
    [1,2,4]三唑并[1,5-c]嘧啶衍

    公开(公告)号：EP1116722A1

    公开(公告)日：2001-07-18

    申请号：EP99944771.7

    申请日：1999-09-22

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： SHIMADA, Junichi ,  IMMA, Hironori ,  OSAKADA, Naoto ,  SHIOZAKI, Shizuo ,  KANDA, Tomoyuki ,  KUWANA, Yoshihisa

    IPC分类号： C07D487/04 ,  A61K31/505

    CPC分类号： C07D487/04

    摘要： [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by the general formula (I)
    or pharmacologically acceptable salts thereof which show adenosine A 2A receptor antogonism, wherein R 1 represents heteroaryl, etc.; R 2 represents hydrogen, etc.; na and nb represent each an integer of 0 to 4; Q represents hydrogen, etc.; R 4 and R 5 represent each lower alkyl or aryl, or R 4 form together with the adjacent carbon atom a saturated carbon ring when R 3 is any of (i) to (iii); or R 4 represent each hydrogen, lower alkyl or aryl, or R 4 and R 5 form together with the adjacent carbon atom a saturated carbon ring when R 3 is (iv).

    摘要翻译： 由通式（I）表示的Ä1,2,4'-三唑并[1,5-c]嘧啶衍生物或其药理学上可接受的盐，其显示腺苷A2A受体阴性，其中R 1表示杂芳基等; R 2表示氢等; na和nb表示0〜4的整数， Q表示氢等。 当R 3是（i）至（iii）中的任何一个时，R 4和R 5各自表示低级烷基或芳基，或R 4与相邻碳原子一起形成饱和碳环。 或R 4表示当R 3为（ⅳ）时，每个氢，低级烷基或芳基，或R 4和R 5与相邻碳原子一起形成饱和碳环。

    [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
    4.
    发明公开
    [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES 失效
    [1,2,4]三唑并[1,5-c]嘧啶衍

    公开(公告)号：EP0976753A1

    公开(公告)日：2000-02-02

    申请号：EP98909835.5

    申请日：1998-03-24

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： TSUMUKI, Hiroshi ,  SHIMADA, Junichi ,  IMMA, Hironori ,  NAKAMURA, Akiko ,  NONAKA, Hiromi ,  SHIOZAKI, Shizuo ,  ICHIKAWA, Shunji ,  KANDA, Tomoyuki ,  KUWANA, Yoshihisa ,  ICHIMURA, Michio ,  SUZUKI, Fumio

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A 2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A 2A receptors (for example, Parkinson's disease or senile dementia):
    wherein R 1 represents substituted or unsubstituted aryl, or the like; R 2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R 3 represents hydrogen, halogen, XR 10 (wherein X represents O or S; and R 10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.

    摘要翻译： 提供了由式（I）表示的三氮唑-1,5-c嘧啶衍生物或其药学上可接受的盐，其具有腺苷A2A受体拮抗作用，并且可用于治疗或预防腺苷A2A受体多动症诱导的各种疾病（对于 例如，帕金森病或老年痴呆）：其中R 1表示取代或未取代的芳基等; R 2表示氢，卤素，低级烷基，取代或未取代的芳基等; R 3表示氢，卤素，XR 10（其中X表示O或S; R 10表示取代或未取代的芳基，取代或未取代的芳族杂环，取代或未取代的芳烷基，低级烷基或羟基 低级烷基）等; Q表示氢或3,4-二甲氧基苄基。