公开(公告)号：EP1932910A1

公开(公告)日：2008-06-18

申请号：EP06783178.4

申请日：2006-09-05

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： ITO, Mikito ,  MASUDA, Kimie ,  MORI, Hideo ,  KATO, Makiko

IPC分类号： C12N15/09 ,  C12N1/21 ,  C12P7/56

CPC分类号： C12N9/0006 ,  C12N9/1085 ,  C12P7/56

摘要： The present invention provides microorganisms, in which the activity of 4-hydroxybenzoate polyprenyltransferase or 2-octaprenylphenol→2-octaprenyl-6-methoxyphenol flavin reductase is reduced or lost, and which have an ability to produce lactic acid, in particular, microorganisms comprising a chromosomal DNA in which a gene encoding a protein having 4-hydroxybenzoate polyprenyltransferase activity or a protein having 2-octaprenylphenol→2-octaprenyl-6-methoxyphenol flavin reductase activity is partially or completely defective; and a process for producing lactic acid using the microorganisms.

摘要翻译： 本发明提供了微生物，其中4-羟基苯甲酸酯聚异戊二烯基转移酶或2-辛二烯基苯酚†' - 2-辛烯基-6-甲氧基苯酚黄素还原酶的活性被降低或丧失，并且具有生产乳酸的能力，特别是包含 编码具有4-羟基苯甲酸酯聚丙烯酰基转移酶活性的蛋白质的基因或具有2-辛酰丙基苯酚†'2-辛酰基-6-甲氧基苯酚黄素还原酶活性的蛋白质的染色体DNA部分或完全缺陷; 以及使用微生物生产乳酸的方法。