公开(公告)号：EP0668280A1

公开(公告)日：1995-08-23

申请号：EP94925621.8

申请日：1994-09-02

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： MACHII, Daisuke ,  MATSUNO, Kenji ,  KINOSHITA, Iwao ,  NOMOTO, Yuji ,  TAKAI, Haruki ,  OHNO, Tetsuji ,  NAGASHIMA, Ken ,  ISHIKAWA, Tomoko ,  YAMADA, Koji ,  ICHIMURA, Michio ,  KASE, Kiroshi

IPC分类号： C07D487/04 ,  A61K31/505

CPC分类号： C07D487/04

摘要： An imidazoquinazoline derivative represented by formula (I) or a pharmacologically acceptable salt thereof, wherein R 1 andR 2 may be the same or different from each other and each represents hydrogen, lower alkyl, lower alkenyl, aryl, etc.; R 3 represents hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aryl, etc.; and X represents O or S. This compound has a potent and selective cCMP-specific PDE inhibitor activity and is useful for treating or mitigating cardiovascular diseases such as thrombosis, angina pectoris, hypertension and arteriosclerosis, asthma, and so forth.

摘要翻译： 由式（I）表示的咪唑并喹唑啉衍生物或其药学上可接受的盐，其中R 1和R 2可以相同或不同，各自表示氢，低级烷基，低级烯基，芳基等; R 3表示氢，低级烷基，环烷基，低级烯基，芳基等; X表示O或S.该化合物具有有效和选择性的cCMP特异性PDE抑制剂活性，可用于治疗或缓解心血管疾病如血栓形成，心绞痛，高血压和动脉硬化，哮喘等。