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    XANTHINE DERIVATIVE
    2.
    发明公开
    XANTHINE DERIVATIVE 失效
    黄嘌呤衍生物

    公开(公告)号：EP0698607A1

    公开(公告)日：1996-02-28

    申请号：EP95909968.0

    申请日：1995-02-23

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： SUZUKI, Fumio ,  KOIKE, Nobuaki ,  SHIMADA, Junichi ,  NAKAMURA, Joji ,  SHIOZAKI, Shizuo ,  KITAMURA, Shigeto ,  ICHIKAWA, Shunji ,  KASE, Hiroshi ,  NONAKA, Hiromi

    IPC分类号： C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/06

    摘要： A xanthine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R¹, R² and R³ are the same or different from one another and each represents hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R⁴ represents lower alkyl or (un)substituted aryl; R⁵ and R⁶ are the same or different from each other and each represents hydrogen, lower alkyl or lower alkoxy, or R⁵ and R⁶ are combined together to represent -O-(CH₂) p -O- (wherein p represents an integer of 1 to 3); n represents 0, 1 or 2; and m represents 1 or 2. The compound has an adenosine A₂ receptor antagonism and is useful for treating or preventing various diseases caused by the hyperfunctioning of adenosine A₂ receptors, such as Parkinson's disease, senile dementia, depression, asthma or osteoporosis.

    摘要翻译： 由通式（I）表示的黄嘌呤衍生物或其药学上可接受的盐，其中R 1，R 2和R 3彼此相同或不同，各自表示氢，低级烷基，低级烯基 或低级炔基; R 4表示低级烷基或（取代）取代的芳基; R 5和R 6彼此相同或不同，各自表示氢，低级烷基或低级烷氧基，或者R 5和R 6组合在一起，表示-O-（CH 2）p O - （其中p表示1〜3的整数）; n表示0,1或2; m表示1或2.该化合物具有腺苷A2受体拮抗作用，可用于治疗或预防由腺苷A2受体如帕金森病，老年性痴呆，抑郁症，哮喘或骨质疏松症功能障碍引起的各种疾病。

    ADENOSINE INCORPORATION INHIBITOR
    3.
    发明公开
    ADENOSINE INCORPORATION INHIBITOR 失效
    腺苷纳入抑制剂

    公开(公告)号：EP0638567A1

    公开(公告)日：1995-02-15

    申请号：EP94907052.8

    申请日：1994-02-16

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： FUJIWARA, Shigeki ,  MACHII, Daisuke ,  TAKAI, Haruki ,  NONAKA, Hiromi ,  KASE, Hiroshi ,  YAO, Kozo ,  KAWAKAGE, Michiyo ,  KUSAKA, Hideaki ,  KARASAWA, Akira

    IPC分类号： C07D401/14 ,  C07D491/056 ,  A61K31/505

    CPC分类号： C07D401/14 ,  C07D491/04

    摘要： An adenosine incorporation inhibitor and a drug for protecting cardiac muscles or preventing or treating inflammatory edema, each containing as the active ingredient a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R¹ represents hydrogen, (un)substituted lower alkyl, alkenyl or (un)substituted aralkyl; R², R³, R⁴ and R⁵ represent each independently hydrogen, halogen, amino, mono- or di(lower alkyl) amino, lower alkanoyl amino, nitro, cyano, (un)substituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy or lower alkanoyloxy; R⁶, R⁷, R⁸ and R⁹ represent each independently hydrogen, hydroxy, (un)substituted lower alkoxy or aralkyloxy, or alternatively the two adjacent groups among them may be combined together to represent methylenedioxy; R¹⁰ represents hydrogen or lower alkyl; and Y and Z represent each independently N or C-R'', wherein R'' represents hydrogen, (un)substituted lower alkyl or halogen.

    摘要翻译： 一种腺苷结合抑制剂和保护心肌的药物或预防或治疗炎性水肿的药物，每种药物含有作为活性成分的由通式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物或 其中R 1代表氢，（未）取代的低级烷基，烯基或（未）取代的芳烷基; （低级烷基）氨基，低级烷酰基氨基，硝基，氰基，（未）取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基 ，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 8，R 8和R 8各自独立地代表氢，羟基，（未）取代的低级烷氧基或芳烷氧基，或者它们中的两个相邻基团可以结合在一起表示亚甲二氧基; R 10代表氢或低级烷基; Y和Z各自独立地代表N或C-R“，其中R”代表氢，（未）取代的低级烷基或卤素。