公开(公告)号：EP0744409A1

公开(公告)日：1996-11-27

申请号：EP95909967.2

申请日：1995-02-23

申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

发明人： YAMASAKI, Motoo ,  OKABE, Masami ,  SUZAWA, Toshiyuki ,  KOBAYASHI, Ken ,  MARUYAMA, Kumiko

IPC分类号： C07K14/535 ,  A61K38/19

CPC分类号： C07K14/535 ,  A61K38/00

摘要： The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.

摘要翻译： 本发明涉及一种多肽，其中具有人粒细胞集落刺激因子活性的多肽分子中的氨基，羧基，巯基或胍基中的至少一个由化学修饰剂化学修饰，并且包含所述多肽的血小板产生启动子， 用于治疗血小板计数降低的患者的方法包括向患者施用有效量的所述多肽，所述多肽用于制备药物组合物的用途，所述药物组合物可用于治疗血小板计数降低的患者， 用减少的血小板计数治疗患者，其包含药学上可接受的剂型中的有效剂量的所述多肽与药学上可接受的载体。

公开(公告)号：EP0630898A1

公开(公告)日：1994-12-28

申请号：EP93919687.9

申请日：1993-09-20

申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

发明人： TAMAOKI, Tatsuya ,  SHIOTSU, Yukimasa ,  MURAKATA, Chikara ,  AKINAGA, Shiro ,  OKABE, Masami ,  SAITOH, Yutaka ,  WATANABE, Junichi ,  SHIRAKI, Takako

IPC分类号： C07D487/14 ,  C07D498/22 ,  C07H19/23 ,  A61K31/55 ,  A61K31/71 ,  A61K31/40

CPC分类号： C07D498/22 ,  C07H9/06 ,  C07H19/044

摘要： A thrombocytopenia remedy containing an indolocarbazole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, and a novel indolocarbazole derivative.

摘要翻译： 含有由通式（I）表示的吲哚并咔唑衍生物或其药理学可接受的盐作为活性成分的血小板减少症治疗剂和新的吲哚咔唑衍生物。