公开(公告)号：EP1110960A4

公开(公告)日：2001-12-12

申请号：EP99940590

申请日：1999-08-31

申请人： KYOWA HAKKO KOGYO KK

发明人： HARA MITSUNOBU ,  NAKASHIMA TAKAYUKI ,  KANDA YUTAKA ,  HAMANO MASAMI ,  IKEDA SHUN-ICHI ,  UOSAKI YUKO ,  MIIKE YOKO ,  KANAZAWA JUNJI

IPC分类号： A61K31/00 ,  A61K31/365 ,  C07D407/14 ,  C07H17/08 ,  C07D307/93 ,  A61K31/34 ,  A61K31/70 ,  C07D307/94 ,  C07D407/12 ,  C07D493/08

CPC分类号： C07D407/14 ,  A61K31/00 ,  A61K31/365 ,  C07H17/08

摘要： Apoptosis inducing agents which contain as the active ingredient tetrocarcin derivatives represented by general formula (I) or salts thereof. These agents are useful as drugs for preventing and/or treating diseases caused by the accelerated expression of proteins of the Bc1-2 family such as cancer and AIDS; wherein --- represents a single or double bond; j and k are each 0 or 1; R?1 to R3, R7 to R10 and R14¿ represent each hydrogen, lower alkyl, etc.; R?4, R11, R12, R13 and R15 to R18¿ represent each hydrogen, hydroxy, lower alkyl, etc.; R?5 and R6¿ represent each hydrogen, hydroxy, lower alkyl or (B) (wherein R32 represents formyl, etc.; and R?33 to R35¿ represent each hydrogen, hydroxy, lower alkyl, etc.); and R19 represents hydroxy, lower alkoxy, lower alkanoyloxy, etc.