公开(公告)号：EP1097934A4

公开(公告)日：2001-10-04

申请号：EP99929753

申请日：1999-07-08

申请人： KYOWA HAKKO KOGYO KK

发明人： AKAMA TSUTOMU ,  NAGATA HIROYUKI ,  HASEGAWA ATSUHIRO ,  UE HARUMI ,  TAKAHASHI ISAMI ,  SAITOH YUTAKA ,  MOCHIDA KENICHI ,  IKEDA SHUN-ICHI ,  KANDA YUTAKA

IPC分类号： A61P37/06 ,  C07D471/06 ,  A61K31/47

CPC分类号： C07D471/06

摘要： LK6-A derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which exhibit immunosuppressive, cytostatic and antitumor effects and so on, wherein R1 is a lower alkanoyl or acryloyl group which may be substituted with, e.g., lower alkoxy, or the like; R2 is hydrogen, halogeno or the like; R2' is hydrogen, or R2' together with R3 forms a bond; R3 is optionally substituted lower alkanoyl, or R3 together with R2' forms a bond; R?4 and R5¿ are each hydrogen, optionally substituted lower alkanoyl or the like; R6 is hydrogen or the like; and R?7 and R8¿ are each hydrogen, optionally substituted lower alkanoyl or the like, with the proviso that LK6-A corresponding to a compound of general formula (I) where R1 is (E)-methoxyacryloyl; R?2, R4, R5, R6 and R7¿ are each hydrogen; R8 is acetyl; and R?2' and R3¿ together form a bond is excepted.

公开(公告)号：EP1329511A4

公开(公告)日：2005-01-19

申请号：EP01970146

申请日：2001-09-19

申请人： KYOWA HAKKO KOGYO KK

发明人： MIYAJI HIROMASA ,  HARUOKA MOTOKO ,  NAGATA HIROYUKI ,  OTA TOSHIO ,  KAWABATA AYAKO ,  SUGANO SUMIO ,  NAKAMURA YUSUKE

IPC分类号： A61K38/00 ,  A61P5/38 ,  A61P7/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P39/00 ,  C07K16/40 ,  C12N1/21 ,  C12N9/16 ,  C12N9/20 ,  C12N15/55 ,  C12N5/10 ,  C12Q1/68

CPC分类号： C12N9/16 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/20

摘要： A novel phospholipase A2 polypeptide; DNA encoding this polypeptide; a vector containing this DNA; a transformant transformed by this vector; and a process for producing the above phospholipase A2 polypeptide. Methods of using the above polypeptide, for example, a method of screening a compound having an agonist or antagonist activity by using this polypeptide or an antibody thereto; and drugs containing this polypeptide or its antibody. A polypeptide (hereinafter referred to simply as the inhibitory polypeptide) inhibiting the phospholipase A2 activity of the phospholipase A2 polypeptide; DNA encoding the inhibitory polypeptide; a vector containing the DNA encoding the inhibitory polypeptide; a transformant transformed by this vector; drugs containing this inhibitory polypeptide; and a process for producing the inhibitory polypeptide.