公开(公告)号：EP0786252A4

公开(公告)日：1998-01-07

申请号：EP95932191

申请日：1995-09-20

申请人： KYOWA HAKKO KOGYO KK

发明人： SAITO HIROMITSU ,  AMISHIRO NOBUYOSHI ,  NAGAMURA SATORU ,  KOBAYASHI EIJI ,  OKAMOTO AKIHIKO ,  GOMI KATSUSHIGE ,  YAMASHITA KINYA ,  SATO KIYOSHI ,  NAKAKURA MASASHI ,  HAYAKAWA EIJI

IPC分类号： C07D487/04 ,  C07D487/10 ,  A61K31/40

CPC分类号： C07D487/04 ,  C07D487/10

摘要： An antitumor agent against drug-fast tumors containing a compound represented by general formula (2) or (a) or a pharmacologically acceptable salt thereof as the active ingredient; wherein X represents Cl or Br; and R represents NR1R2 (wherein R?1 and R2¿ represent each independently hydrogen or C¿1?-C4 linear or branched alkyl) or a group of formula (b) (wherein R?3¿ represents CH¿2? or N-CH3). The agent has an excellent antitumor activity against drug-insensitive tumors and is useful as an antitumor agent against drug-fast tumors.

公开(公告)号：EP1698640A4

公开(公告)日：2008-09-17

申请号：EP04773700

申请日：2004-10-01

申请人： KYOWA HAKKO KOGYO KK

发明人： UENO YUJI ,  KAYASHITA TAKASHI ,  ISHIHARA ATSUSHI ,  NAKAKURA MASASHI ,  YAMAUCHI KYOKO

IPC分类号： C07K16/00 ,  A61K9/00 ,  A61K9/08 ,  A61K39/395 ,  A61K47/12 ,  A61K47/18 ,  C07K16/46

CPC分类号： A61K9/0019 ,  A61K39/39591 ,  A61K47/12 ,  A61K47/183 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/76

摘要： It is intended to provide a method of inhibiting the formation of a soluble aggregate of an antibody in a solution; a method of inhibiting the formation of a chemically degraded product; and a method of stabilizing an antibody. It is also intended to provide a solution-type antibody preparation in which the formation of a soluble aggregate is inhibited; a solution-type antibody preparation in which the formation of a chemically degraded product is inhibited; a solution-type antibody preparation in which the formation of a soluble aggregate, the formation of a chemically degraded product and the formation of an insoluble aggregate are inhibited; an agent for inhibiting the formation of a soluble aggregate of an antibody; an agent for inhibiting the formation of a chemically degraded product of an antibody; and an antibody stabilizer.