公开(公告)号：EP3564207A1

公开(公告)日：2019-11-06

申请号：EP17888899.6

申请日：2017-12-27

申请人： Kaneka Corporation

发明人： MACHIDA, Koji ,  YASUKOUCHI, Hiroaki ,  NISHIYAMA, Akira

IPC分类号： C07C67/03 ,  C07C33/22 ,  C07C69/12 ,  C07D249/08 ,  C07B61/00

摘要： The present invention provides a method for obtaining an alcohol compound from an ester compound with high purity and by easy operation.
The high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.

公开(公告)号：EP3124470B1

公开(公告)日：2020-01-08

申请号：EP15769421.7

申请日：2015-03-23

申请人： Kaneka Corporation

发明人： MACHIDA, Koji ,  MORI, Kohei ,  KISHIMOTO, Narumi ,  TAKEDA, Toshihiro

IPC分类号： C07C277/08 ,  C07C279/24

公开(公告)号：EP3680235A1

公开(公告)日：2020-07-15

申请号：EP18853393.9

申请日：2018-08-07

申请人： Kaneka Corporation

发明人： YASUKOUCHI, Hiroaki ,  NISHIYAMA, Akira ,  MACHIDA, Koji

IPC分类号： C07D217/06

摘要： The purpose of the present invention is to further enhance a product yield when a phosgene alternative reagent is used in a flow reactor. A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution of the nitrogen-containing organic compound, wherein the raw material liquid C is a reaction substrate having functional group capable of reacting with phosgene, the functional group being selected from the group consisting of an amino group, an amido group, and -OC(=O)NH 2 , or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

公开(公告)号：EP3348549A1

公开(公告)日：2018-07-18

申请号：EP16844277.0

申请日：2016-09-01

申请人： Kaneka Corporation

发明人： MACHIDA, Koji ,  NISHIYAMA, Akira

IPC分类号： C07D251/24 ,  B32B7/02 ,  G02B5/30

CPC分类号： C07D251/24 ,  B32B7/02 ,  G02B1/14 ,  G02B5/30

摘要： The present invention provides methods respectively for producing a 2,4,6-tris(2-hydroxy-3-methyl-4-alkoxyphenyl)-1,3,5-triazine compound and 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine, both of which are improved in yield and quality. The methods according to the present invention are characterized in that a reaction of 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine with an alkylating agent is carried out using a base in the presence of an alcohol or water, and are also characterized in that an ester compound is used as an additive in a reaction of cyanuric chloride with 2-methylresorcinol.

公开(公告)号：EP3124470A1

公开(公告)日：2017-02-01

申请号：EP15769421.7

申请日：2015-03-23

申请人： Kaneka Corporation

发明人： MACHIDA, Koji ,  MORI, Kohei ,  KISHIMOTO, Narumi ,  TAKEDA, Toshihiro

IPC分类号： C07C277/08 ,  C07C279/24

摘要： A tri-carbobenzoxy-arginine represented by the following formula (2):

is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof:

by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

摘要翻译： 由下式（2）表示的三碳代苯甲酰氧基 - 精氨酸：通过对由下式（1）表示的精氨酸或精氨酸衍生物（1）或其盐进行苄氧羰基化生产：通过加入苄氧苯甲酰氯和碱 水/有机溶剂双层体系转化为式（1）表示的精氨酸或精氨酸衍生物（1）或其盐。