公开(公告)号：EP3733155A1

公开(公告)日：2020-11-04

申请号：EP18895719.5

申请日：2018-12-27

申请人： Kao Corporation

发明人： SUZUKI, Takashi ,  ABE, Tetsuya ,  TAKAHASHI, Rui ,  ENDO, Koji ,  HAGURA, Toyoki ,  IWAI, Hidetaka ,  HORIZUMI, Teruo ,  AOSAKI, Taisuke ,  UDA, Akihiro ,  NAKAMICHI, Masato

IPC分类号： A61K8/34 ,  A61K8/02 ,  A61K8/37 ,  A61K9/08 ,  A61K47/10

摘要： To provide a new method for producing a composition containing a hardly water-soluble aromatic compound, the composition having outstanding hardly water-soluble aromatic compound.
A method for producing a composition containing a hardly water-soluble aromatic compound, comprising:
Step (1) of obtaining a hardly water-soluble aromatic compound solution 1, Step (1) comprising Step (1-1) of preparing a material for heating comprising (A) a hardly water-soluble aromatic compound, (B) a polyol, and (C) an aqueous medium, and Step (1-2) of obtaining a heated solution containing a hardly water-soluble aromatic compound by heating the material for heating at normal pressure at a temperature of less than 100°C; and
Step (2) of obtaining a hardly water-soluble aromatic compound solution 2 by adding water to the hardly water-soluble aromatic compound solution 1 such that the hardly water-soluble aromatic compound solution 2 has a concentration of the (A) hardly water-soluble aromatic compound above a saturation solubility at 25°C, wherein, in Step (1), a content of a surfactant in the material for heating is 0.1 mass% or less and a content of the (A) hardly water-soluble aromatic compound in the material for heating is below a saturation solubility of the (A) hardly water-soluble aromatic compound in a solvent having the same composition at 25°C.