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    POLYPEPTIDE HUMANIN INHIBITING NERVE CELL DEATH
    1.
    发明公开
    POLYPEPTIDE HUMANIN INHIBITING NERVE CELL DEATH 有权
    POLYPEPTID，HUMANIN，WELCHES DAS ABSTERBEN VON NERVENZELLEN HEMMT

    公开(公告)号：EP1221480A1

    公开(公告)日：2002-07-10

    申请号：EP00961024.7

    申请日：2000-09-14

    申请人： Keio University

    发明人： Nishimoto, Ikuo Keio University School of Medicine

    IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47 ,  C07K7/08 ,  C07K16/18 ,  A61K48/00 ,  A61K38/10 ,  A61K38/17 ,  A61P25/28 ,  A61P25/00

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K2319/00

    摘要： The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease mutant APP can be induced by ecdysone treatment, a gene that protects the neurons from cell death was successfully isolated. The gene encodes a secretory polypeptide consisting of 24 amino acids, and this polypeptide suppresses neuronal death caused by the expression of APP mutants and presenilin mutants. The polypeptide also suppressed cell death of primary neuronal culture caused by Aβ. Furthermore, by mutating the amino acids of the polypeptide, the neuronal death suppression activity of the polypwptide was successfully and significantly enhanced. These polypeptides and derivatives thereof are useful as pharamaceuticals to prevent neuronal death associated with Alzheimer's disease, and as seed compounds for developing novel pharmaceuticals for Alzheimer's disease.

    摘要翻译： 本发明提供抑制与阿尔茨海默病有关的神经元死亡的多肽。 使用神经元细胞系统，其中家族性阿尔茨海默氏病突变体APP的表达可以通过蜕皮激素治疗诱导，成功分离了保护神经元免于细胞死亡的基因。 该基因编码由24个氨基酸组成的分泌多肽，并且该多肽抑制由APP突变体和早老素突变体的表达引起的神经元死亡。 多肽还抑制由Aβ引起的原代神经元培养的细胞死亡。 此外，通过突变多肽的氨基酸，成功并显着增强了聚磷酸的神经元死亡抑制活性。 这些多肽及其衍生物可用作药物以防止与阿尔茨海默病相关的神经元死亡，以及用于开发用于阿尔茨海默氏病的新型药物的种子化合物。