摘要:
To provide a peptide having high affinity for hemagglutinin and a peptide having high inhibitory activity against influenza virus infection, as well as a pharmaceutical composition containing such peptides, the polypeptides having any one of SEQ ID NOs: 2 to 7, 9 to 10, and 12 to 18 are obtained by introducing mutation into a peptide having the sequence of ARLSPTMVHPNGAQP (peptide A-1: SEQ ID NO: 1) and screening for peptides having higher affinity for hemagglutinin. Further, the inhibitory activity of the peptide of SEQ ID NO: 3 against influenza virus infection can be enhanced by truncating the C-terminus of SEQ ID NO: 3 with leaving ARLPR or ARLP. In addition, an influenza virus-infection inhibitor and an influenza preventive/therapeutic agent can be prepared by formulating these influenza virus receptor-binding peptides.
摘要翻译:为了提供对血凝素的高亲和力和具有针对甲型流感病毒感染抑制活性高的肽的肽,以及含有寻求肽的药物组合物,具有该多肽为SEQ ID NO中的任一个:2月9日至10日至7,和 12至18中引入突变而具有ARLSPTMVHPNGAQP的序列的肽获得(:SEQ ID NO:肽A-1 1)和筛选具有血凝素较高的亲和力的肽。 此外,SEQ ID NO:2的肽的抑制活性:与离开ARLPR或ARLP 3:针对流感病毒感染3可以通过截短SEQ ID NO:2的C端来增强。 除了流感病毒感染抑制剂和流感的预防/治疗剂可通过配制论文流感病毒的受体结合的肽来制备。
摘要:
The present invention relates to a method for producing oligosaccharides comprising giving saccharide primers to human cells, plant cells or yeast, and a method for producing oligosaccharides comprising giving saccharide primers to cells (excluding COS-7 cells) cultured using a high-density culturing method. The oligosaccharides are applicable to drugs, pharmaceuticals, diagnostic agents, sugar chain tips etc.
摘要:
The present invention provides a self-assembly of a compound or of a pharmaceutically acceptable salt thereof, the compound being represented by formula (I)
R 1 -Gly LeuAla Met Ala Pro Ser Val Gly His ValArg Gln His Gly-R 2 (I)
(wherein R 1 represents a linear or branched acyl group having 14 to 24 carbon atoms; R 2 represents OH, NH2, NR 3 R 4 , a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryloxy group, or a substituted or unsubstituted aralkyloxy group; and R 3 and R 4 independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, an alkoxy group, or a hydroxy group, provided that both R 3 and R 4 do not represent a hydroxy group or an alkoxy group simultaneously).
摘要翻译:本发明提供化合物或其药学上可接受的盐的自组装,所述化合物由式(I)表示。ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -Gly LeuAla Met Ala Pro Ser Val Gly His ValArg Gln His Gly-R 2€ƒ€ƒ€ƒ(I)(其中R 1表示具有14至24个碳原子的直链或支链酰基; R 2表示OH,NH 2 NR 3 R 4,取代或未取代的烷氧基,取代或未取代的芳氧基或取代或未取代的芳烷氧基; R 3和R 4分别独立地表示取代或未取代的烷基,取代或未取代的芳基, 取代或未取代的芳烷基,烷氧基或羟基,条件是R 3和R 4同时不表示羟基或烷氧基)。