专利检索 ap:("Kinemed, Inc.") AND inv:"FANARA, Patrizia A." 第 1 页

1.

发明公开
METHOD FOR MEASURING DYNAMICS OF SELF-ASSEMBLING SYSTEMS OF BIOLOGICAL MOLECULES IN VIVO AND USES FOR DISCOVERING OR EVALUATING THERAPEUTIC AGENTS 审中-公开
标题翻译：测量动态系统SELBSTANLAGERNDER生物分子的体内方法，并使用发现与评估药物的

公开(公告)号：EP1784647A1

公开(公告)日：2007-05-16

申请号：EP05784429.2

申请日：2005-08-08

申请人： Kinemed, Inc.

发明人： HELLERSTEIN, Marc K. , FANARA, Patrizia A.

IPC分类号： G01N33/58 , G01N33/68 , A61K49/00

CPC分类号： G01N33/58 , G01N33/6896 , G01N2458/15 , G01N2500/00

摘要： The Applicants have established a simple, rapid assay of measuring the dynamics of self-assembling systems of biological molecules, based on stable isotope labeling technology that can be used in intact animals including humans. Examples of self-assembling systems of biological molecules include microtubule polymers, actin filaments, amyloid-beta plaques or fibrils, prion plaques or fibrils, fibrin aggregates, tau filaments (e.g., neurofibrillary tangles), α-synuclein filaments, and mutant hemoglobin aggregates. The method reveals constitutive differences in the dynamics of assembly and disassembly between tissues and is sensitive to the action of compounds that stabilize these dynamics.