公开(公告)号：EP1411046B1

公开(公告)日：2009-09-16

申请号：EP02738777.8

申请日：2002-06-21

申请人： Kirin Pharma Kabushiki Kaisha

发明人： FUJIWARA, Yasunari, c/o Kirin Beer K.K. ,  SENGA, Terufumi, c/o Kirin Beer K.K. ,  NISHITOBA, Tsuyoshi, c/o Kirin Beer K.K. ,  OSAWA, Tatsushi, c/o Kirin Beer K.K. ,  MIWA, Atsushi, c/o Kirin Beer K.K. ,  NAKAMURA, Kazuhide, c/o Kirin Beer K.K.

IPC分类号： C07D215/22 ,  C07D239/86 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： A compound having strong antitumor activity. It is a compound represented by the formula (I) or a pharmaceutically acceptable salt or solvate of the compound: (I) [wherein X is CH or nitrogen; Z is oxygen or sulfur; L is oxygen or sulfur; M is CR10R11 (R10 and R11 each is hydrogen, alkyl, or alkoxy) or NR12 (R12 is hydrogen or alkyl); R1, R2, R3 each is hydrogen or optionally substituted alkoxy; R4 is hydrogen; R5 to R8 each is hydrogen, halogeno, alkoxy, etc.; and R9 is -R14, alkyl optionally substituted by -T-R15 or -NR16R17 (T is oxygen, sulfur, or NH; R14 is an optionally substituted carbon ring or heterocycle; and R15 to R17 each is alkyl or an optionally substituted carbon ring or heterocycle), -NR18R19 (R18 and R19 each is hydrogen, optionally substituted alkyl, or an optionally substituted carbon ring or heterocycle), or an optionally substituted carbon ring or heterocycle].