公开(公告)号：EP3088353A1

公开(公告)日：2016-11-02

申请号：EP14875349.4

申请日：2014-12-26

Applicant: Korea Advanced Institute Of Science And Technology

Inventor： JON, Sang Yong ,  LEE, Yong Hyun

IPC: B82B1/00 ,  A61K47/48

Abstract: The present invention provides a bilirubin nanoparticle formed by the self-assembly of bilirubin and a composite comprising a hydrophilic polymer, a use thereof, and a preparation method therefor. The bilirubin nanoparticle according to the present invention can release a drug enclosed therein to the outside by being collapsed by light or active oxygen stimulation. The bilirubin nanoparticle according to the present invention exhibits antioxidant, antiangiogenic, anticancer, and anti-inflammatory activities.

Abstract translation: 本发明提供通过胆红素的自组装形成的胆红素纳米粒子和包含亲水性聚合物的复合物及其用途及其制备方法。 根据本发明的胆红素纳米颗粒可以通过光或活性氧刺激使其中封闭的药物释放到外部。 根据本发明的胆红素纳米颗粒表现出抗氧化，抗血管生成，抗癌和抗炎活性。

公开(公告)号：EP3919471A1

公开(公告)日：2021-12-08

申请号：EP21735834.0

申请日：2021-04-06

Applicant: Korea Advanced Institute of Science and Technology

Inventor： JON, Sang Yong ,  CHUNG, Chan Ho ,  JUNG, Wonsik ,  RAHMAN, Afia Tasnim

IPC: C07C69/157 ,  A61K31/216 ,  A61K9/14 ,  A61K9/16 ,  A61K47/12 ,  A61P29/00

Abstract: The present disclosure relates to a rosmarinic acid derivative, rosmarinic acid-derived particles, and a composition containing same for treating an inflammatory disease. The use of the rosmarinic acid derivative and rosmarinic acid-derived particles of the present disclosure enables the utilization of rosmarinic acid, which has been restricted in the utilization thereof due to low water solubility and low bioavailability, for a medicinal purpose.

公开(公告)号：EP3088353B1

公开(公告)日：2019-12-18

申请号：EP14875349.4

申请日：2014-12-26

Applicant: Korea Advanced Institute Of Science And Technology

Inventor： JON, Sang Yong ,  LEE, Yong Hyun

IPC: A61K47/60 ,  A61K47/69 ,  A61K31/704 ,  B82B1/00 ,  B82Y5/00 ,  A61P35/00 ,  A61P29/00

Abstract: The present invention provides a bilirubin nanoparticle formed by the self-assembly of bilirubin and a composite comprising a hydrophilic polymer, a use thereof, and a preparation method therefor. The bilirubin nanoparticle according to the present invention can release a drug enclosed therein to the outside by being collapsed by light or active oxygen stimulation. The bilirubin nanoparticle according to the present invention exhibits antioxidant, antiangiogenic, anticancer, and anti-inflammatory activities.