公开(公告)号：EP4272739A1

公开(公告)日：2023-11-08

申请号：EP21915823.5

申请日：2021-12-29

Applicant: Korea Advanced Institute of Science and Technology

Inventor： CHO, Kwang Hyun ,  KIM, Nam Hee ,  HWANG, Chae Young ,  KIM, Tae Young

IPC: A61K31/496 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04

Abstract: The present invention relates to a composition for inhibiting metastasis and enhancing anticancer drug sensitiviy, the composition removing, from cancer cells, stem cell properties and heterogeneity acquired by epithelial-to-mesenchymal transition (EMT), thereby being capable of inducing the cancer cells into a phenotype which has regained responsiveness to a chemotherapeutic agent. A combination of a p53 activator, a SMAD4 inhibitor and an ERK inhibitor of the present invention enables a mesenchymal cell phenotype to return to an epithelial cell phenotype, and also enables the ability of cancer cells to metastasize to be inhibited by overcoming the high plasticity and drug resistance of the cancer cells, and thus may be widely used in the field of cancer treatment.