公开(公告)号：EP4497836A1

公开(公告)日：2025-01-29

申请号：EP23775342.1

申请日：2023-03-23

Applicant: Korea Advanced Institute of Science and Technology

Inventor： CHO, Kwang Hyun ,  GONG, Jeong Ryeol ,  LEE, Chun Kyung ,  KIM, Hoon Min ,  KIM, Ju Hee

IPC: C12Q1/6886 ,  C12N5/09 ,  C12N15/85 ,  A61P35/00

Abstract: The present invention relates to a method for constructing a gene network through a single-cell transcriptome and a method for discovering key genes in differentiation using same, and a composition for the prevention, alleviation, or treatment of colon cancer using the target discovered through the method. The method for constructing a gene network of key genes according to the present invention employs single-cell transcriptome data and thus can be applied to all single-cell transcriptome data. The combination of MYB/HDAC2/FOXA2 discovered upon application to colon cells can serve as a cancer treatment target that promotes the differentiation of colon cancer cells to revert same into differentiated normal cells.