公开(公告)号：EP4455664A1

公开(公告)日：2024-10-30

申请号：EP22912037.3

申请日：2022-12-23

Applicant: Korea Advanced Institute of Science and Technology

Inventor： CHO, Kwang Hyun ,  LEE, Hye Min ,  GONG, Jeong Ryeol

IPC: G01N33/50 ,  A61P35/00

Abstract: The present invention relates to a composition comprising a TAF10 inhibitor for preventing or treating colorectal cancer. The inhibition of TAF10 was found to lead to suppressing the growth and proliferation of colorectal cancer cells, reducing vascularization, and inhibiting the WNT signaling pathway, and increase the survival rate of patients as analyzed with a large-scale cancer database. In particular, reversal of the cancerization process, which is the differentiation of colorectal cancer cells into normal cells, was confirmed. Unlike conventional anticancer agents that simply induce the death of cancer cells, the present invention can thus be advantageously utilized as a treatment method for converting colorectal cancer cells into normal cells while excluding side effects of normal cell death that may occur during anticancer treatment.