公开(公告)号：EP4498085A1

公开(公告)日：2025-01-29

申请号：EP23775311.6

申请日：2023-03-22

Applicant: Korea Advanced Institute of Science and Technology

Inventor： CHO, Kwang Hyun ,  LEE, Jung Eun ,  GONG, Jeong Ryeol

IPC: G01N33/50

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of cancer, comprising a DEAD-box helicase 54 (DDX54) inhibitor and a cancer immunotherapy agent, and to a combination therapy of cancer immunotherapy. The DDX54 inhibitor according to the present invention can enhance the efficacy of cancer immunotherapy when used in combination with a cancer immunotherapy agent, and the composition containing the DDX54 inhibitor and a cancer immunotherapy agent inhibits proliferation of cancer, which is a key characteristic thereof, and simultaneously inhibits a signal transduction pathway known as an immune evasion mechanism, and thus may be provided for the prevention or treatment of cancer.