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公开(公告)号：EP3360561A1
公开(公告)日：2018-08-15
申请号：EP16853956.7
申请日：2016-10-10
发明人： JO, Sung-Kee , PARK, Hae Ran , JUNG, Uhee , LEE, Ho Yong , CHO, Hyang Hee
IPC分类号： A61K36/232 , A61K36/234 , A61K36/65 , A61K31/7048 , A61K31/352 , A23L33/105 , A23L33/10
摘要： The present invention relates to a method for preparing an herbal composition with increased fat-soluble polyphenols, an herbal composition prepared by the method, and a use of the composition. The herbal composition with increased fat-soluble polyphenols of the present invention is characterized by the significantly increased content of fat-soluble polyphenols including decursin, compared with the herbal composition of comparative example, and also demonstrates a significant anti-oxidative activity, immune cell activating effect, and cancer cell growth inhibitory effect, significantly reduces renal toxicity and liver toxicity induced by the anticancer agent cisplatin back so as to be almost normal condition, and significantly inhibits the intestinal crypt loss caused by irradiation, compared with the herbal composition of comparative example. Therefore, the herbal composition with increased fat-soluble polyphenols of the present invention can be effectively used as a composition for cancer treatment, an anti-cancer adjuvant, a composition for enhancing immune function, a composition for protecting a living body, and a composition for preventing side effects of cancer treatment.
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公开(公告)号：EP3360561B1
公开(公告)日：2020-03-04
申请号：EP16853956.7
申请日：2016-10-10
发明人： JO, Sung-Kee , PARK, Hae Ran , JUNG, Uhee , LEE, Ho Yong , CHO, Hyang Hee
IPC分类号： A61K36/232 , A61K36/234 , A61K36/65 , A61K31/7048 , A61K31/352 , A23L33/105 , A23L33/10 , A61P37/04 , A61P35/00
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公开(公告)号：EP3365355A1
公开(公告)日：2018-08-29
申请号：EP17813605.7
申请日：2017-06-15
发明人： KIM, In Gyu , KIM, Seo Yeon , LEE, Jei Ha , CHOI, Soo Im , KIM, Min Sik , KIM, Jung Yul , SHIN, Byungchul , JUNG, Uhee
CPC分类号： A61K38/02 , A61K38/00 , A61P35/04 , C07K7/08 , C07K14/4702
摘要： The present invention relates to a peptide suppressing the phosphorylation of threonine (T120), the 120th residue of TSPYL5 (testis-specific Y-like protein 5), which is specifically as follows. The present inventors constructed T120D, the mutant of the 120th residue threonine (T120) of TSPYL5, and T120A-TSPYL5 gene and then transfected cells with them in order to investigate the effect of phosphorylation on T120 residue. As a result, wild-type TSPYL5 and T120D moved into nucleus and stayed there. But in the case of T120A-TSPYL5, TSPYL5 did not move into nucleus and instead it was expressed only in cytoplasm. The protein could not bind to AKT, either. Instead, ubiquitination of TSPYL5 was increased but SUMOylation was inhibited. Also, the expressions of ALDH1-A1, -A3, CD44 gene and protein were reduced, and thereby the growth and metastasis of lung cancer cells were suppressed and sphere formation was reduced. Based on the observation above, the inventors constructed the peptide composed of the amino acid sequences represented by SEQ. ID. NO: 43 or NO: 44 that could inhibit phosphorylation of the 120th residue threonine of TSPYL5. The said peptide can be effectively used as a composition for the inhibition of cancer cell growth, metastasis, and cancer stem cell growth.
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