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1.发明公开PHARMACEUTICAL COMPOSITION CONTAINING FIBULIN-3 PROTEIN AS AN ACTIVE INGREDIENT FOR INHIBITING THE GROWTH OF CANCER STEM CELLS 有权WITH纤蛋白-3蛋白的药物组合物作为活性FOR抑制肿瘤干细胞的生长
公开(公告)号：EP2742950A1
公开(公告)日：2014-06-18
申请号：EP11870806.4
申请日：2011-12-22
发明人： KIM, In-Gyu , SHIN, Byungchul , KIM, Kug Chan , KIM, Seo Yeon , KIM, Min Jung , LEE, So Yong
CPC分类号： A61K38/1738 , A61K38/00 , C07K14/78
摘要： The present invention relates to fibulin-3 protein and a pharmaceutical composition comprising the fibulin-3 protein as an active ingredient for inhibiting the growth of cancer stem cells. More particularly, in cancer stem cells separated from H460 and A549 cells, which are non-small-cell lung cancer cells, using ALDH1 activity as a marker, fibulin-3 induces the reductions of wnt/β-catenin, MMP2 and 7, which display characteristics of cancer stem cells, thereby decreasing the activated growth and penetration of the cancer stem cells. In addition, the purified fibulin-3 protein inhibits the growth of the non-small-cell lung cancer cell line A549, the breast cancer cell line MDA-MB231, and the cancer stem cell line active ALDH1. Therefore, fibulin-3 can be valuably used as an active ingredient of the pharmaceutical composition for inhibiting the growth of cancer stem cells.
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2.发明授权PHARMACEUTICAL COMPOSITION CONTAINING FIBULIN-3 PROTEIN AS AN ACTIVE INGREDIENT FOR INHIBITING THE GROWTH OF CANCER STEM CELLS 有权WITH纤蛋白-3蛋白的药物组合物作为活性FOR抑制肿瘤干细胞的生长
公开(公告)号：EP2742950B1
公开(公告)日：2017-03-08
申请号：EP11870806.4
申请日：2011-12-22
发明人： KIM, In-Gyu , SHIN, Byungchul , KIM, Kug Chan , KIM, Seo Yeon , KIM, Min Jung , LEE, So Yong
CPC分类号： A61K38/1738 , A61K38/00 , C07K14/78
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